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The Epidemiology of HIV and HSV-2 Infections among Women Participating in Microbicide and Vaccine Feasibility Studies in Northern Tanzania

OBJECTIVES: To prepare for future HIV prevention trials, we conducted prospective cohort studies among women working in food and recreational facilities in northern Tanzania. We examined the prevalence and incidence of HIV and HSV-2, and associated risk factors. METHODS: Women aged 18–44 years worki...

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Autores principales: Kapiga, Saidi H., Ewings, Fiona M., Ao, Tony, Chilongani, Joseph, Mongi, Aika, Baisley, Kathy, Francis, Suzanna, Andreasen, Aura, Hashim, Ramadhan, Watson-Jones, Deborah, Changalucha, John, Hayes, Richard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3715536/
https://www.ncbi.nlm.nih.gov/pubmed/23874780
http://dx.doi.org/10.1371/journal.pone.0068825
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author Kapiga, Saidi H.
Ewings, Fiona M.
Ao, Tony
Chilongani, Joseph
Mongi, Aika
Baisley, Kathy
Francis, Suzanna
Andreasen, Aura
Hashim, Ramadhan
Watson-Jones, Deborah
Changalucha, John
Hayes, Richard
author_facet Kapiga, Saidi H.
Ewings, Fiona M.
Ao, Tony
Chilongani, Joseph
Mongi, Aika
Baisley, Kathy
Francis, Suzanna
Andreasen, Aura
Hashim, Ramadhan
Watson-Jones, Deborah
Changalucha, John
Hayes, Richard
author_sort Kapiga, Saidi H.
collection PubMed
description OBJECTIVES: To prepare for future HIV prevention trials, we conducted prospective cohort studies among women working in food and recreational facilities in northern Tanzania. We examined the prevalence and incidence of HIV and HSV-2, and associated risk factors. METHODS: Women aged 18–44 years working in food and recreational facilities were screened to determine their eligibility for the studies. Between 2008–2010, HIV-negative women were enrolled and followed for 12 months. At enrolment and 3-monthly, we collected socio-demographic and behavioural data, and performed clinical examinations for collection of biological specimens that were tested for reproductive tract infections. Risk factors for HIV and HSV-2 incidence were investigated using Poisson regression models. RESULTS: We screened 2,229 and enrolled 1,378 women. The median age was 27 years (interquartile range, IQR 22, 33), and median duration working at current facility was 2 years. The prevalences of HIV at screening and HSV-2 at enrolment were 16% and 67%, respectively. Attendance at the 12-month visit was 86%. HIV and HSV-2 incidence rates were 3.7 (95% confidence interval, CI: 2.8,5.1) and 28.6 (95% CI: 23.5,35.0)/100 person-years, respectively. Women who were separated, divorced, or widowed were at increased risk of HIV (adjusted incidence rate ratio, aRR = 6.63; 95% CI: 1.97,22.2) and HSV-2 (aRR = 2.00; 95% CI: 1.15,3.47) compared with married women. Women reporting ≥3 partners in the past 3 months were at higher HIV risk compared with women with 0–1 partner (aRR = 4.75; 95% CI: 2.10,10.8), while those who had reached secondary education or above were at lower risk of HSV-2 compared with women with incomplete primary education (aRR = 0.42; 95% CI: 0.22,0.82). CONCLUSIONS: HIV and HSV-2 rates remain substantially higher in this cohort than in the general population, indicating urgent need for effective interventions. These studies demonstrate the feasibility of conducting trials to test new interventions in this highly-mobile population.
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spelling pubmed-37155362013-07-19 The Epidemiology of HIV and HSV-2 Infections among Women Participating in Microbicide and Vaccine Feasibility Studies in Northern Tanzania Kapiga, Saidi H. Ewings, Fiona M. Ao, Tony Chilongani, Joseph Mongi, Aika Baisley, Kathy Francis, Suzanna Andreasen, Aura Hashim, Ramadhan Watson-Jones, Deborah Changalucha, John Hayes, Richard PLoS One Research Article OBJECTIVES: To prepare for future HIV prevention trials, we conducted prospective cohort studies among women working in food and recreational facilities in northern Tanzania. We examined the prevalence and incidence of HIV and HSV-2, and associated risk factors. METHODS: Women aged 18–44 years working in food and recreational facilities were screened to determine their eligibility for the studies. Between 2008–2010, HIV-negative women were enrolled and followed for 12 months. At enrolment and 3-monthly, we collected socio-demographic and behavioural data, and performed clinical examinations for collection of biological specimens that were tested for reproductive tract infections. Risk factors for HIV and HSV-2 incidence were investigated using Poisson regression models. RESULTS: We screened 2,229 and enrolled 1,378 women. The median age was 27 years (interquartile range, IQR 22, 33), and median duration working at current facility was 2 years. The prevalences of HIV at screening and HSV-2 at enrolment were 16% and 67%, respectively. Attendance at the 12-month visit was 86%. HIV and HSV-2 incidence rates were 3.7 (95% confidence interval, CI: 2.8,5.1) and 28.6 (95% CI: 23.5,35.0)/100 person-years, respectively. Women who were separated, divorced, or widowed were at increased risk of HIV (adjusted incidence rate ratio, aRR = 6.63; 95% CI: 1.97,22.2) and HSV-2 (aRR = 2.00; 95% CI: 1.15,3.47) compared with married women. Women reporting ≥3 partners in the past 3 months were at higher HIV risk compared with women with 0–1 partner (aRR = 4.75; 95% CI: 2.10,10.8), while those who had reached secondary education or above were at lower risk of HSV-2 compared with women with incomplete primary education (aRR = 0.42; 95% CI: 0.22,0.82). CONCLUSIONS: HIV and HSV-2 rates remain substantially higher in this cohort than in the general population, indicating urgent need for effective interventions. These studies demonstrate the feasibility of conducting trials to test new interventions in this highly-mobile population. Public Library of Science 2013-07-18 /pmc/articles/PMC3715536/ /pubmed/23874780 http://dx.doi.org/10.1371/journal.pone.0068825 Text en © 2013 Kapiga et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Kapiga, Saidi H.
Ewings, Fiona M.
Ao, Tony
Chilongani, Joseph
Mongi, Aika
Baisley, Kathy
Francis, Suzanna
Andreasen, Aura
Hashim, Ramadhan
Watson-Jones, Deborah
Changalucha, John
Hayes, Richard
The Epidemiology of HIV and HSV-2 Infections among Women Participating in Microbicide and Vaccine Feasibility Studies in Northern Tanzania
title The Epidemiology of HIV and HSV-2 Infections among Women Participating in Microbicide and Vaccine Feasibility Studies in Northern Tanzania
title_full The Epidemiology of HIV and HSV-2 Infections among Women Participating in Microbicide and Vaccine Feasibility Studies in Northern Tanzania
title_fullStr The Epidemiology of HIV and HSV-2 Infections among Women Participating in Microbicide and Vaccine Feasibility Studies in Northern Tanzania
title_full_unstemmed The Epidemiology of HIV and HSV-2 Infections among Women Participating in Microbicide and Vaccine Feasibility Studies in Northern Tanzania
title_short The Epidemiology of HIV and HSV-2 Infections among Women Participating in Microbicide and Vaccine Feasibility Studies in Northern Tanzania
title_sort epidemiology of hiv and hsv-2 infections among women participating in microbicide and vaccine feasibility studies in northern tanzania
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3715536/
https://www.ncbi.nlm.nih.gov/pubmed/23874780
http://dx.doi.org/10.1371/journal.pone.0068825
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