R-loops and nicks initiate DNA breakage and genome instability in non-growing Escherichia coli

Double-stranded DNA ends, often from replication, drive genomic instability, yet their origin in non-replicating cells is unknown. Here we show that transcriptional RNA/DNA hybrids (R-loops) generate DNA ends that underlie stress-induced mutation and amplification. Depleting RNA/DNA hybrids with ove...

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Detalles Bibliográficos
Autores principales: Wimberly, Hallie, Shee, Chandan, Thornton, P. C., Sivaramakrishnan, Priya, Rosenberg, Susan M., Hastings, P. J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Pub. Group 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3715873/
https://www.ncbi.nlm.nih.gov/pubmed/23828459
http://dx.doi.org/10.1038/ncomms3115

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