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Diabetic myonecrosis: a diagnostic challenge in patients with long-standing diabetes
A 51-year-old female with a history of type 1 diabetes mellitus (DM) presented with sudden onset of pain and swelling of the left thigh. Her initial evaluation revealed mildly elevated erythrocyte sedimentation rate and creatine phosphokinase. Venous and arterial Doppler studies were negative for DV...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Co-Action Publishing
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3716030/ https://www.ncbi.nlm.nih.gov/pubmed/23882392 http://dx.doi.org/10.3402/jchimp.v3i1.20494 |
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author | Bhasin, Robin Ghobrial, Ibrahim |
author_facet | Bhasin, Robin Ghobrial, Ibrahim |
author_sort | Bhasin, Robin |
collection | PubMed |
description | A 51-year-old female with a history of type 1 diabetes mellitus (DM) presented with sudden onset of pain and swelling of the left thigh. Her initial evaluation revealed mildly elevated erythrocyte sedimentation rate and creatine phosphokinase. Venous and arterial Doppler studies were negative for DVT and arterial thrombus. Further imaging with CT scan and then MRI revealed an irregular, enhancing space-occupying lesion of the left upper and mid-thigh. Subsequent muscle biopsy showed myonecrosis and proliferative myositis. Both findings are consistent with diabetic myonecrosis, which is a microvascular complication of long-standing poorly controlled DM. The patient was treated with analgesics, supportive care, and optimization of glycemic control. While short-term prognosis is good with adequate healing in a few weeks to several months, long-term prognosis is poor due to underlying extensive vascular disease. Although radiological findings are very suggestive of the diagnosis, most clinicians still need tissue biopsy to rule out other serious conditions such as infections and malignancy. |
format | Online Article Text |
id | pubmed-3716030 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Co-Action Publishing |
record_format | MEDLINE/PubMed |
spelling | pubmed-37160302013-07-23 Diabetic myonecrosis: a diagnostic challenge in patients with long-standing diabetes Bhasin, Robin Ghobrial, Ibrahim J Community Hosp Intern Med Perspect Case Report A 51-year-old female with a history of type 1 diabetes mellitus (DM) presented with sudden onset of pain and swelling of the left thigh. Her initial evaluation revealed mildly elevated erythrocyte sedimentation rate and creatine phosphokinase. Venous and arterial Doppler studies were negative for DVT and arterial thrombus. Further imaging with CT scan and then MRI revealed an irregular, enhancing space-occupying lesion of the left upper and mid-thigh. Subsequent muscle biopsy showed myonecrosis and proliferative myositis. Both findings are consistent with diabetic myonecrosis, which is a microvascular complication of long-standing poorly controlled DM. The patient was treated with analgesics, supportive care, and optimization of glycemic control. While short-term prognosis is good with adequate healing in a few weeks to several months, long-term prognosis is poor due to underlying extensive vascular disease. Although radiological findings are very suggestive of the diagnosis, most clinicians still need tissue biopsy to rule out other serious conditions such as infections and malignancy. Co-Action Publishing 2013-04-17 /pmc/articles/PMC3716030/ /pubmed/23882392 http://dx.doi.org/10.3402/jchimp.v3i1.20494 Text en © 2013 Robin Bhasin and Ibrahim Ghobrial http://creativecommons.org/licenses/by/2.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Case Report Bhasin, Robin Ghobrial, Ibrahim Diabetic myonecrosis: a diagnostic challenge in patients with long-standing diabetes |
title | Diabetic myonecrosis: a diagnostic challenge in patients with long-standing diabetes |
title_full | Diabetic myonecrosis: a diagnostic challenge in patients with long-standing diabetes |
title_fullStr | Diabetic myonecrosis: a diagnostic challenge in patients with long-standing diabetes |
title_full_unstemmed | Diabetic myonecrosis: a diagnostic challenge in patients with long-standing diabetes |
title_short | Diabetic myonecrosis: a diagnostic challenge in patients with long-standing diabetes |
title_sort | diabetic myonecrosis: a diagnostic challenge in patients with long-standing diabetes |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3716030/ https://www.ncbi.nlm.nih.gov/pubmed/23882392 http://dx.doi.org/10.3402/jchimp.v3i1.20494 |
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