Genes and primary headaches: discovering new potential therapeutic targets

Genetic studies have clearly shown that primary headaches (migraine, tension-type headache and cluster headache) are multifactorial disorders characterized by a complex interaction between different genes and environmental factors. Genetic association studies have highlighted a potential role in the...

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Autores principales: Rainero, Innocenzo, Rubino, Elisa, Paemeleire, Koen, Gai, Annalisa, Vacca, Alessandro, De Martino, Paola, Gentile, Salvatore, Sarchielli, Paola, Pinessi, Lorenzo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer 2013
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3716727/
https://www.ncbi.nlm.nih.gov/pubmed/23848401
http://dx.doi.org/10.1186/1129-2377-14-61
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author Rainero, Innocenzo
Rubino, Elisa
Paemeleire, Koen
Gai, Annalisa
Vacca, Alessandro
De Martino, Paola
Gentile, Salvatore
Sarchielli, Paola
Pinessi, Lorenzo
author_facet Rainero, Innocenzo
Rubino, Elisa
Paemeleire, Koen
Gai, Annalisa
Vacca, Alessandro
De Martino, Paola
Gentile, Salvatore
Sarchielli, Paola
Pinessi, Lorenzo
author_sort Rainero, Innocenzo
collection PubMed
description Genetic studies have clearly shown that primary headaches (migraine, tension-type headache and cluster headache) are multifactorial disorders characterized by a complex interaction between different genes and environmental factors. Genetic association studies have highlighted a potential role in the etiopathogenesis of these disorders for several genes related to vascular, neuronal and neuroendocrine functions. A potential role as a therapeutic target is now emerging for some of these genes. The main purpose of this review is to describe new advances in our knowledge regarding the role of MTHFR, KCNK18, TRPV1, TRPV3 and HCRTR genes in primary headache disorders. Involvement of these genes in primary headaches, as well as their potential role in the therapy of these disorders, will be discussed.
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spelling pubmed-37167272013-07-22 Genes and primary headaches: discovering new potential therapeutic targets Rainero, Innocenzo Rubino, Elisa Paemeleire, Koen Gai, Annalisa Vacca, Alessandro De Martino, Paola Gentile, Salvatore Sarchielli, Paola Pinessi, Lorenzo J Headache Pain Review Article Genetic studies have clearly shown that primary headaches (migraine, tension-type headache and cluster headache) are multifactorial disorders characterized by a complex interaction between different genes and environmental factors. Genetic association studies have highlighted a potential role in the etiopathogenesis of these disorders for several genes related to vascular, neuronal and neuroendocrine functions. A potential role as a therapeutic target is now emerging for some of these genes. The main purpose of this review is to describe new advances in our knowledge regarding the role of MTHFR, KCNK18, TRPV1, TRPV3 and HCRTR genes in primary headache disorders. Involvement of these genes in primary headaches, as well as their potential role in the therapy of these disorders, will be discussed. Springer 2013 2013-07-12 /pmc/articles/PMC3716727/ /pubmed/23848401 http://dx.doi.org/10.1186/1129-2377-14-61 Text en Copyright ©2013 Rainero et al.; licensee Springer. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Rainero, Innocenzo
Rubino, Elisa
Paemeleire, Koen
Gai, Annalisa
Vacca, Alessandro
De Martino, Paola
Gentile, Salvatore
Sarchielli, Paola
Pinessi, Lorenzo
Genes and primary headaches: discovering new potential therapeutic targets
title Genes and primary headaches: discovering new potential therapeutic targets
title_full Genes and primary headaches: discovering new potential therapeutic targets
title_fullStr Genes and primary headaches: discovering new potential therapeutic targets
title_full_unstemmed Genes and primary headaches: discovering new potential therapeutic targets
title_short Genes and primary headaches: discovering new potential therapeutic targets
title_sort genes and primary headaches: discovering new potential therapeutic targets
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3716727/
https://www.ncbi.nlm.nih.gov/pubmed/23848401
http://dx.doi.org/10.1186/1129-2377-14-61
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