ATM activation mediates anticancer immunosurveillance by natural killer and T cells

The DNA damage response (DDR), which is frequently activated in cancer cells, has been proposed to operate as an early barrier against oncogenesis. We have recently shown that ATM mediates the spontaneous regression of Eμ-myc-driven murine B-cell leukemia in a natural killer and T cell-dependent man...

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Detalles Bibliográficos
Autores principales: Tang, Melissa LF, Gasser, Stephan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2013
Materias:
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3716735/
https://www.ncbi.nlm.nih.gov/pubmed/23894700
http://dx.doi.org/10.4161/onci.24438
Descripción
Sumario:The DNA damage response (DDR), which is frequently activated in cancer cells, has been proposed to operate as an early barrier against oncogenesis. We have recently shown that ATM mediates the spontaneous regression of Eμ-myc-driven murine B-cell leukemia in a natural killer and T cell-dependent manner. The DDR partially enhanced immune recognition by stimulating the expression of the DNAM-1 ligand CD155.

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