ATM activation mediates anticancer immunosurveillance by natural killer and T cells

The DNA damage response (DDR), which is frequently activated in cancer cells, has been proposed to operate as an early barrier against oncogenesis. We have recently shown that ATM mediates the spontaneous regression of Eμ-myc-driven murine B-cell leukemia in a natural killer and T cell-dependent man...

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Detalles Bibliográficos
Autores principales: Tang, Melissa LF, Gasser, Stephan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2013
Materias:
Author's View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3716735/
https://www.ncbi.nlm.nih.gov/pubmed/23894700
http://dx.doi.org/10.4161/onci.24438
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author Tang, Melissa LF
Gasser, Stephan
author_facet Tang, Melissa LF
Gasser, Stephan
author_sort Tang, Melissa LF
collection PubMed
description The DNA damage response (DDR), which is frequently activated in cancer cells, has been proposed to operate as an early barrier against oncogenesis. We have recently shown that ATM mediates the spontaneous regression of Eμ-myc-driven murine B-cell leukemia in a natural killer and T cell-dependent manner. The DDR partially enhanced immune recognition by stimulating the expression of the DNAM-1 ligand CD155.
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spelling pubmed-37167352013-07-26 ATM activation mediates anticancer immunosurveillance by natural killer and T cells Tang, Melissa LF Gasser, Stephan Oncoimmunology Author's View The DNA damage response (DDR), which is frequently activated in cancer cells, has been proposed to operate as an early barrier against oncogenesis. We have recently shown that ATM mediates the spontaneous regression of Eμ-myc-driven murine B-cell leukemia in a natural killer and T cell-dependent manner. The DDR partially enhanced immune recognition by stimulating the expression of the DNAM-1 ligand CD155. Landes Bioscience 2013-06-01 2013-05-08 /pmc/articles/PMC3716735/ /pubmed/23894700 http://dx.doi.org/10.4161/onci.24438 Text en Copyright © 2013 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Author's View
Tang, Melissa LF
Gasser, Stephan
ATM activation mediates anticancer immunosurveillance by natural killer and T cells
title ATM activation mediates anticancer immunosurveillance by natural killer and T cells
title_full ATM activation mediates anticancer immunosurveillance by natural killer and T cells
title_fullStr ATM activation mediates anticancer immunosurveillance by natural killer and T cells
title_full_unstemmed ATM activation mediates anticancer immunosurveillance by natural killer and T cells
title_short ATM activation mediates anticancer immunosurveillance by natural killer and T cells
title_sort atm activation mediates anticancer immunosurveillance by natural killer and t cells
topic Author's View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3716735/
https://www.ncbi.nlm.nih.gov/pubmed/23894700
http://dx.doi.org/10.4161/onci.24438
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