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Empowering scFv with effector cell functions for improved anticancer therapeutics
Single chain variable fragment (scFv) constructs have been an important source of high affinity reagents to target cancer cells. Including an immunoglobulin Fc-binding domain can empower scFvs and other tumor antigen-binding proteins with immune effector cell functions and hence significantly increa...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Landes Bioscience
2013
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3716736/ https://www.ncbi.nlm.nih.gov/pubmed/23894701 http://dx.doi.org/10.4161/onci.24439 |
| Sumario: | Single chain variable fragment (scFv) constructs have been an important source of high affinity reagents to target cancer cells. Including an immunoglobulin Fc-binding domain can empower scFvs and other tumor antigen-binding proteins with immune effector cell functions and hence significantly increase their therapeutic potential. |
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