Empowering scFv with effector cell functions for improved anticancer therapeutics

Single chain variable fragment (scFv) constructs have been an important source of high affinity reagents to target cancer cells. Including an immunoglobulin Fc-binding domain can empower scFvs and other tumor antigen-binding proteins with immune effector cell functions and hence significantly increa...

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Detalles Bibliográficos
Autor principal: Zhang, Hongtao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2013
Materias:
Author's View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3716736/
https://www.ncbi.nlm.nih.gov/pubmed/23894701
http://dx.doi.org/10.4161/onci.24439
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author Zhang, Hongtao
author_facet Zhang, Hongtao
author_sort Zhang, Hongtao
collection PubMed
description Single chain variable fragment (scFv) constructs have been an important source of high affinity reagents to target cancer cells. Including an immunoglobulin Fc-binding domain can empower scFvs and other tumor antigen-binding proteins with immune effector cell functions and hence significantly increase their therapeutic potential.
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spelling pubmed-37167362013-07-26 Empowering scFv with effector cell functions for improved anticancer therapeutics Zhang, Hongtao Oncoimmunology Author's View Single chain variable fragment (scFv) constructs have been an important source of high affinity reagents to target cancer cells. Including an immunoglobulin Fc-binding domain can empower scFvs and other tumor antigen-binding proteins with immune effector cell functions and hence significantly increase their therapeutic potential. Landes Bioscience 2013-06-01 2013-05-08 /pmc/articles/PMC3716736/ /pubmed/23894701 http://dx.doi.org/10.4161/onci.24439 Text en Copyright © 2013 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Author's View
Zhang, Hongtao
Empowering scFv with effector cell functions for improved anticancer therapeutics
title Empowering scFv with effector cell functions for improved anticancer therapeutics
title_full Empowering scFv with effector cell functions for improved anticancer therapeutics
title_fullStr Empowering scFv with effector cell functions for improved anticancer therapeutics
title_full_unstemmed Empowering scFv with effector cell functions for improved anticancer therapeutics
title_short Empowering scFv with effector cell functions for improved anticancer therapeutics
title_sort empowering scfv with effector cell functions for improved anticancer therapeutics
topic Author's View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3716736/
https://www.ncbi.nlm.nih.gov/pubmed/23894701
http://dx.doi.org/10.4161/onci.24439
work_keys_str_mv AT zhanghongtao empoweringscfvwitheffectorcellfunctionsforimprovedanticancertherapeutics

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