Importance of helper T-cell activation in dendritic cell-based anticancer immunotherapy

Dendritic cell-based anticancer immunotherapy is feasible, safe and results in the induction of tumor-specific immune responses, at least in a fraction of vaccinated patients. The concomitant activation of cytotoxic and helper T cells, by loading DCs with peptides or electroporating them with the co...

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Autores principales: Schreibelt, Gerty, Bol, Kalijn F., Aarntzen, Erik HJG, Gerritsen, Winald R, Punt, Cornelis JA, Figdor, Carl G, de Vries, I Jolanda M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2013
Materias:
Author's View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3716737/
https://www.ncbi.nlm.nih.gov/pubmed/23894702
http://dx.doi.org/10.4161/onci.24440
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author Schreibelt, Gerty
Bol, Kalijn F.
Aarntzen, Erik HJG
Gerritsen, Winald R
Punt, Cornelis JA
Figdor, Carl G
de Vries, I Jolanda M
author_facet Schreibelt, Gerty
Bol, Kalijn F.
Aarntzen, Erik HJG
Gerritsen, Winald R
Punt, Cornelis JA
Figdor, Carl G
de Vries, I Jolanda M
author_sort Schreibelt, Gerty
collection PubMed
description Dendritic cell-based anticancer immunotherapy is feasible, safe and results in the induction of tumor-specific immune responses, at least in a fraction of vaccinated patients. The concomitant activation of cytotoxic and helper T cells, by loading DCs with peptides or electroporating them with the corresponding mRNAs, may further enhance vaccine-induced antitumor responses.
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spelling pubmed-37167372013-07-26 Importance of helper T-cell activation in dendritic cell-based anticancer immunotherapy Schreibelt, Gerty Bol, Kalijn F. Aarntzen, Erik HJG Gerritsen, Winald R Punt, Cornelis JA Figdor, Carl G de Vries, I Jolanda M Oncoimmunology Author's View Dendritic cell-based anticancer immunotherapy is feasible, safe and results in the induction of tumor-specific immune responses, at least in a fraction of vaccinated patients. The concomitant activation of cytotoxic and helper T cells, by loading DCs with peptides or electroporating them with the corresponding mRNAs, may further enhance vaccine-induced antitumor responses. Landes Bioscience 2013-06-01 2013-05-14 /pmc/articles/PMC3716737/ /pubmed/23894702 http://dx.doi.org/10.4161/onci.24440 Text en Copyright © 2013 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Author's View
Schreibelt, Gerty
Bol, Kalijn F.
Aarntzen, Erik HJG
Gerritsen, Winald R
Punt, Cornelis JA
Figdor, Carl G
de Vries, I Jolanda M
Importance of helper T-cell activation in dendritic cell-based anticancer immunotherapy
title Importance of helper T-cell activation in dendritic cell-based anticancer immunotherapy
title_full Importance of helper T-cell activation in dendritic cell-based anticancer immunotherapy
title_fullStr Importance of helper T-cell activation in dendritic cell-based anticancer immunotherapy
title_full_unstemmed Importance of helper T-cell activation in dendritic cell-based anticancer immunotherapy
title_short Importance of helper T-cell activation in dendritic cell-based anticancer immunotherapy
title_sort importance of helper t-cell activation in dendritic cell-based anticancer immunotherapy
topic Author's View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3716737/
https://www.ncbi.nlm.nih.gov/pubmed/23894702
http://dx.doi.org/10.4161/onci.24440
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