The S100A8/A9 complex reduces CTLA4 expression by immature myeloid cells: Implications for pancreatic cancer-driven immunosuppression

An expansion of different myeloid derived suppressive cell (MDSC) subsets can be detected in the blood and secondary lymphoid organs of early and advanced pancreatic ductal adenocarcinoma (PDAC) patients. Double negative (CD14(−)HLA-DR(−)) MDSCs are frequently induced by PDACs. In addition, by relea...

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Detalles Bibliográficos
Autores principales: Basso, Daniela, Fogar, Paola, Plebani, Mario
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2013
Materias:
Author's View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3716738/
https://www.ncbi.nlm.nih.gov/pubmed/23894703
http://dx.doi.org/10.4161/onci.24441
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author Basso, Daniela
Fogar, Paola
Plebani, Mario
author_facet Basso, Daniela
Fogar, Paola
Plebani, Mario
author_sort Basso, Daniela
collection PubMed
description An expansion of different myeloid derived suppressive cell (MDSC) subsets can be detected in the blood and secondary lymphoid organs of early and advanced pancreatic ductal adenocarcinoma (PDAC) patients. Double negative (CD14(−)HLA-DR(−)) MDSCs are frequently induced by PDACs. In addition, by releasing S100A8 and S100A9, advanced PDAC lesions cause an expansion of highly immunosuppressive CD33(+)CD14(+)HLA-DR(−) monocytic MDSCs expressing low levels of cytotoxic T lymphocyte antigen 4 (CTLA4) on the cell surface.
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spelling pubmed-37167382013-07-26 The S100A8/A9 complex reduces CTLA4 expression by immature myeloid cells: Implications for pancreatic cancer-driven immunosuppression Basso, Daniela Fogar, Paola Plebani, Mario Oncoimmunology Author's View An expansion of different myeloid derived suppressive cell (MDSC) subsets can be detected in the blood and secondary lymphoid organs of early and advanced pancreatic ductal adenocarcinoma (PDAC) patients. Double negative (CD14(−)HLA-DR(−)) MDSCs are frequently induced by PDACs. In addition, by releasing S100A8 and S100A9, advanced PDAC lesions cause an expansion of highly immunosuppressive CD33(+)CD14(+)HLA-DR(−) monocytic MDSCs expressing low levels of cytotoxic T lymphocyte antigen 4 (CTLA4) on the cell surface. Landes Bioscience 2013-06-01 2013-05-09 /pmc/articles/PMC3716738/ /pubmed/23894703 http://dx.doi.org/10.4161/onci.24441 Text en Copyright © 2013 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Author's View
Basso, Daniela
Fogar, Paola
Plebani, Mario
The S100A8/A9 complex reduces CTLA4 expression by immature myeloid cells: Implications for pancreatic cancer-driven immunosuppression
title The S100A8/A9 complex reduces CTLA4 expression by immature myeloid cells: Implications for pancreatic cancer-driven immunosuppression
title_full The S100A8/A9 complex reduces CTLA4 expression by immature myeloid cells: Implications for pancreatic cancer-driven immunosuppression
title_fullStr The S100A8/A9 complex reduces CTLA4 expression by immature myeloid cells: Implications for pancreatic cancer-driven immunosuppression
title_full_unstemmed The S100A8/A9 complex reduces CTLA4 expression by immature myeloid cells: Implications for pancreatic cancer-driven immunosuppression
title_short The S100A8/A9 complex reduces CTLA4 expression by immature myeloid cells: Implications for pancreatic cancer-driven immunosuppression
title_sort s100a8/a9 complex reduces ctla4 expression by immature myeloid cells: implications for pancreatic cancer-driven immunosuppression
topic Author's View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3716738/
https://www.ncbi.nlm.nih.gov/pubmed/23894703
http://dx.doi.org/10.4161/onci.24441
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