An apolipoprotein A-I mimetic targets scavenger receptor A on tumor-associated macrophages: A prospective anticancer treatment?

Tumor-associated macrophages polarize toward an M2 phenotype and express scavenger receptor A (SRA), hence promoting tumor progression. We demonstrated that SRA can be therapeutically targeted in vivo with the small peptide inhibitor 4F to prevent metastatic spread. Beyond our study, 4F is emerging...

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Autores principales: Neyen, Claudine, Mukhopadhyay, Subhankar, Gordon, Siamon, Hagemann, Thorsten
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2013
Materias:
Author's View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3716741/
https://www.ncbi.nlm.nih.gov/pubmed/23894706
http://dx.doi.org/10.4161/onci.24461
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author Neyen, Claudine
Mukhopadhyay, Subhankar
Gordon, Siamon
Hagemann, Thorsten
author_facet Neyen, Claudine
Mukhopadhyay, Subhankar
Gordon, Siamon
Hagemann, Thorsten
author_sort Neyen, Claudine
collection PubMed
description Tumor-associated macrophages polarize toward an M2 phenotype and express scavenger receptor A (SRA), hence promoting tumor progression. We demonstrated that SRA can be therapeutically targeted in vivo with the small peptide inhibitor 4F to prevent metastatic spread. Beyond our study, 4F is emerging as a promising anticancer agent.
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spelling pubmed-37167412013-07-26 An apolipoprotein A-I mimetic targets scavenger receptor A on tumor-associated macrophages: A prospective anticancer treatment? Neyen, Claudine Mukhopadhyay, Subhankar Gordon, Siamon Hagemann, Thorsten Oncoimmunology Author's View Tumor-associated macrophages polarize toward an M2 phenotype and express scavenger receptor A (SRA), hence promoting tumor progression. We demonstrated that SRA can be therapeutically targeted in vivo with the small peptide inhibitor 4F to prevent metastatic spread. Beyond our study, 4F is emerging as a promising anticancer agent. Landes Bioscience 2013-06-01 2013-05-13 /pmc/articles/PMC3716741/ /pubmed/23894706 http://dx.doi.org/10.4161/onci.24461 Text en Copyright © 2013 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Author's View
Neyen, Claudine
Mukhopadhyay, Subhankar
Gordon, Siamon
Hagemann, Thorsten
An apolipoprotein A-I mimetic targets scavenger receptor A on tumor-associated macrophages: A prospective anticancer treatment?
title An apolipoprotein A-I mimetic targets scavenger receptor A on tumor-associated macrophages: A prospective anticancer treatment?
title_full An apolipoprotein A-I mimetic targets scavenger receptor A on tumor-associated macrophages: A prospective anticancer treatment?
title_fullStr An apolipoprotein A-I mimetic targets scavenger receptor A on tumor-associated macrophages: A prospective anticancer treatment?
title_full_unstemmed An apolipoprotein A-I mimetic targets scavenger receptor A on tumor-associated macrophages: A prospective anticancer treatment?
title_short An apolipoprotein A-I mimetic targets scavenger receptor A on tumor-associated macrophages: A prospective anticancer treatment?
title_sort apolipoprotein a-i mimetic targets scavenger receptor a on tumor-associated macrophages: a prospective anticancer treatment?
topic Author's View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3716741/
https://www.ncbi.nlm.nih.gov/pubmed/23894706
http://dx.doi.org/10.4161/onci.24461
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