Strategies for purging CD96(+) stem cells in vitro and in vivo: New avenues for autologous stem cell transplantation in acute myeloid leukemia

The persistence of leukemic stem cells (LSCs) in acute myeloid leukemia (AML) patients receiving chemotherapy may be responsible for the high frequency of relapse. The selective elimination of CD96(+) AML-LSCs by means of CD96-specific monoclonal antibodies may be a promising therapeutic approach an...

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Autores principales: Staudinger, Matthias, Humpe, Andreas, Gramatzki, Martin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2013
Materias:
Author's View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3716745/
https://www.ncbi.nlm.nih.gov/pubmed/23894710
http://dx.doi.org/10.4161/onci.24500
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author Staudinger, Matthias
Humpe, Andreas
Gramatzki, Martin
author_facet Staudinger, Matthias
Humpe, Andreas
Gramatzki, Martin
author_sort Staudinger, Matthias
collection PubMed
description The persistence of leukemic stem cells (LSCs) in acute myeloid leukemia (AML) patients receiving chemotherapy may be responsible for the high frequency of relapse. The selective elimination of CD96(+) AML-LSCs by means of CD96-specific monoclonal antibodies may be a promising therapeutic approach and revitalize autologous hematopoietic progenitor cell transplantation.
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spelling pubmed-37167452013-07-26 Strategies for purging CD96(+) stem cells in vitro and in vivo: New avenues for autologous stem cell transplantation in acute myeloid leukemia Staudinger, Matthias Humpe, Andreas Gramatzki, Martin Oncoimmunology Author's View The persistence of leukemic stem cells (LSCs) in acute myeloid leukemia (AML) patients receiving chemotherapy may be responsible for the high frequency of relapse. The selective elimination of CD96(+) AML-LSCs by means of CD96-specific monoclonal antibodies may be a promising therapeutic approach and revitalize autologous hematopoietic progenitor cell transplantation. Landes Bioscience 2013-06-01 2013-04-16 /pmc/articles/PMC3716745/ /pubmed/23894710 http://dx.doi.org/10.4161/onci.24500 Text en Copyright © 2013 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Author's View
Staudinger, Matthias
Humpe, Andreas
Gramatzki, Martin
Strategies for purging CD96(+) stem cells in vitro and in vivo: New avenues for autologous stem cell transplantation in acute myeloid leukemia
title Strategies for purging CD96(+) stem cells in vitro and in vivo: New avenues for autologous stem cell transplantation in acute myeloid leukemia
title_full Strategies for purging CD96(+) stem cells in vitro and in vivo: New avenues for autologous stem cell transplantation in acute myeloid leukemia
title_fullStr Strategies for purging CD96(+) stem cells in vitro and in vivo: New avenues for autologous stem cell transplantation in acute myeloid leukemia
title_full_unstemmed Strategies for purging CD96(+) stem cells in vitro and in vivo: New avenues for autologous stem cell transplantation in acute myeloid leukemia
title_short Strategies for purging CD96(+) stem cells in vitro and in vivo: New avenues for autologous stem cell transplantation in acute myeloid leukemia
title_sort strategies for purging cd96(+) stem cells in vitro and in vivo: new avenues for autologous stem cell transplantation in acute myeloid leukemia
topic Author's View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3716745/
https://www.ncbi.nlm.nih.gov/pubmed/23894710
http://dx.doi.org/10.4161/onci.24500
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