Immunotherapy of HPV-associated head and neck cancer: Critical parameters

Various arguments support the development of a vaccine targeting human papillomavirus (HPV) for the treatment of HPV-associated head and neck cancer. However, the mucosal localization of this tumor, the HPV-driven downregulation of MHC Class I molecules and various other immunosuppressive mechanisms...

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Autores principales: Nizard, Mevyn, Sandoval, Federico, Badoual, Cecile, Pere, Helene, Terme, Magali, Hans, Stephane, Benhamouda, Nadine, Granier, Clemence, Brasnu, Daniel, Tartour, Eric
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2013
Materias:
Author's View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3716751/
https://www.ncbi.nlm.nih.gov/pubmed/23894716
http://dx.doi.org/10.4161/onci.24534
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author Nizard, Mevyn
Sandoval, Federico
Badoual, Cecile
Pere, Helene
Terme, Magali
Hans, Stephane
Benhamouda, Nadine
Granier, Clemence
Brasnu, Daniel
Tartour, Eric
author_facet Nizard, Mevyn
Sandoval, Federico
Badoual, Cecile
Pere, Helene
Terme, Magali
Hans, Stephane
Benhamouda, Nadine
Granier, Clemence
Brasnu, Daniel
Tartour, Eric
author_sort Nizard, Mevyn
collection PubMed
description Various arguments support the development of a vaccine targeting human papillomavirus (HPV) for the treatment of HPV-associated head and neck cancer. However, the mucosal localization of this tumor, the HPV-driven downregulation of MHC Class I molecules and various other immunosuppressive mechanisms must be carefully considered to improve the clinical efficacy of such an immunotherapeutic strategy.
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spelling pubmed-37167512013-07-26 Immunotherapy of HPV-associated head and neck cancer: Critical parameters Nizard, Mevyn Sandoval, Federico Badoual, Cecile Pere, Helene Terme, Magali Hans, Stephane Benhamouda, Nadine Granier, Clemence Brasnu, Daniel Tartour, Eric Oncoimmunology Author's View Various arguments support the development of a vaccine targeting human papillomavirus (HPV) for the treatment of HPV-associated head and neck cancer. However, the mucosal localization of this tumor, the HPV-driven downregulation of MHC Class I molecules and various other immunosuppressive mechanisms must be carefully considered to improve the clinical efficacy of such an immunotherapeutic strategy. Landes Bioscience 2013-06-01 2013-04-16 /pmc/articles/PMC3716751/ /pubmed/23894716 http://dx.doi.org/10.4161/onci.24534 Text en Copyright © 2013 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Author's View
Nizard, Mevyn
Sandoval, Federico
Badoual, Cecile
Pere, Helene
Terme, Magali
Hans, Stephane
Benhamouda, Nadine
Granier, Clemence
Brasnu, Daniel
Tartour, Eric
Immunotherapy of HPV-associated head and neck cancer: Critical parameters
title Immunotherapy of HPV-associated head and neck cancer: Critical parameters
title_full Immunotherapy of HPV-associated head and neck cancer: Critical parameters
title_fullStr Immunotherapy of HPV-associated head and neck cancer: Critical parameters
title_full_unstemmed Immunotherapy of HPV-associated head and neck cancer: Critical parameters
title_short Immunotherapy of HPV-associated head and neck cancer: Critical parameters
title_sort immunotherapy of hpv-associated head and neck cancer: critical parameters
topic Author's View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3716751/
https://www.ncbi.nlm.nih.gov/pubmed/23894716
http://dx.doi.org/10.4161/onci.24534
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