Toward understanding the genetics of regulatory T cells in ovarian cancer

Tumor-infiltrating regulatory T cells (Tregs) promote immune evasion and are associated with poor disease outcome in patients affected by various malignancies. We have recently demonstrated that several, inherited single nucleotide polymorphisms affecting Treg-related genes influence the survival of...

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Autores principales: DeRycke, Melissa S, Charbonneau, Bridget, Preston, Claudia C, Kalli, Kimberly R, Knutson, Keith L, Rider, David N, Goode, Ellen L
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2013
Materias:
Author's View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3716752/
https://www.ncbi.nlm.nih.gov/pubmed/23894717
http://dx.doi.org/10.4161/onci.24535
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author DeRycke, Melissa S
Charbonneau, Bridget
Preston, Claudia C
Kalli, Kimberly R
Knutson, Keith L
Rider, David N
Goode, Ellen L
author_facet DeRycke, Melissa S
Charbonneau, Bridget
Preston, Claudia C
Kalli, Kimberly R
Knutson, Keith L
Rider, David N
Goode, Ellen L
author_sort DeRycke, Melissa S
collection PubMed
description Tumor-infiltrating regulatory T cells (Tregs) promote immune evasion and are associated with poor disease outcome in patients affected by various malignancies. We have recently demonstrated that several, inherited single nucleotide polymorphisms affecting Treg-related genes influence the survival of ovarian cancer patients, providing novel insights into possible mechanisms of immune escape.
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spelling pubmed-37167522013-07-26 Toward understanding the genetics of regulatory T cells in ovarian cancer DeRycke, Melissa S Charbonneau, Bridget Preston, Claudia C Kalli, Kimberly R Knutson, Keith L Rider, David N Goode, Ellen L Oncoimmunology Author's View Tumor-infiltrating regulatory T cells (Tregs) promote immune evasion and are associated with poor disease outcome in patients affected by various malignancies. We have recently demonstrated that several, inherited single nucleotide polymorphisms affecting Treg-related genes influence the survival of ovarian cancer patients, providing novel insights into possible mechanisms of immune escape. Landes Bioscience 2013-06-01 2013-04-16 /pmc/articles/PMC3716752/ /pubmed/23894717 http://dx.doi.org/10.4161/onci.24535 Text en Copyright © 2013 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Author's View
DeRycke, Melissa S
Charbonneau, Bridget
Preston, Claudia C
Kalli, Kimberly R
Knutson, Keith L
Rider, David N
Goode, Ellen L
Toward understanding the genetics of regulatory T cells in ovarian cancer
title Toward understanding the genetics of regulatory T cells in ovarian cancer
title_full Toward understanding the genetics of regulatory T cells in ovarian cancer
title_fullStr Toward understanding the genetics of regulatory T cells in ovarian cancer
title_full_unstemmed Toward understanding the genetics of regulatory T cells in ovarian cancer
title_short Toward understanding the genetics of regulatory T cells in ovarian cancer
title_sort toward understanding the genetics of regulatory t cells in ovarian cancer
topic Author's View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3716752/
https://www.ncbi.nlm.nih.gov/pubmed/23894717
http://dx.doi.org/10.4161/onci.24535
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