Anti-platelet-activating factor, antibacterial, and antiradical activities of lipids extract from silver carp brain

BACKGROUND: Epidemiological studies have verified the protective role of fish lipids in cardiovascular diseases. However, the effects of fish lipids on health boost remain undefined. Large amounts of by-products, such as fish brain which contains high level of lipids, are produced with silver carp p...

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Autores principales: Wang, Caixia, Xia, Wenshui, Xu, Yanshun, Jiang, Qixing, Yin, Shanshan, Yang, Yuwei, Yu, Peipie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3717004/
https://www.ncbi.nlm.nih.gov/pubmed/23805935
http://dx.doi.org/10.1186/1476-511X-12-94
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author Wang, Caixia
Xia, Wenshui
Xu, Yanshun
Jiang, Qixing
Yin, Shanshan
Yang, Yuwei
Yu, Peipie
author_facet Wang, Caixia
Xia, Wenshui
Xu, Yanshun
Jiang, Qixing
Yin, Shanshan
Yang, Yuwei
Yu, Peipie
author_sort Wang, Caixia
collection PubMed
description BACKGROUND: Epidemiological studies have verified the protective role of fish lipids in cardiovascular diseases. However, the effects of fish lipids on health boost remain undefined. Large amounts of by-products, such as fish brain which contains high level of lipids, are produced with silver carp processing. Fish brain is rich in bioactive lipids which are overwhelmingly effective in preventing cardiovascular diseases. The aim of this study was to elucidate the pharmacological activities of silver carp brain lipids against diseases by inhibiting platelet-activating factor (PAF), suppressing bacterial growth and scavenging free radicals. METHODS: Total lipids (TL) were extracted from silver carp brain and separated into polar lipids (PL) and neutral lipids (NL). The capabilities of the lipid fractions in aggregating washed rabbit platelet or in inhibiting PAF-induced platelet aggregation were tested. Their antibacterial and antiradical activities were studied as well. RESULTS: The lipid fractions exhibited strong inhibitory activities, and the activity of TL was mainly attributed to NL. TL exhibited antibacterial activity towards Staphylococcus aureus, while NL managed to fight against S. aureus and Escherichia coli. PL excelled TL and NL in simultaneously suppressing the growths of Shigella dysenteriae and Salmonella typhi besides those of S. aureus and E. coli. The scavenging effect of PL on 2,2-diphenyl-1-picrylhydrazyl radical was considerably higher than those of TL and NL. CONCLUSION: The present study may help to explain the protective role of fish lipids against diseases and may be responsible for the effectiveness of fish brain in benefiting health.
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spelling pubmed-37170042013-07-23 Anti-platelet-activating factor, antibacterial, and antiradical activities of lipids extract from silver carp brain Wang, Caixia Xia, Wenshui Xu, Yanshun Jiang, Qixing Yin, Shanshan Yang, Yuwei Yu, Peipie Lipids Health Dis Research BACKGROUND: Epidemiological studies have verified the protective role of fish lipids in cardiovascular diseases. However, the effects of fish lipids on health boost remain undefined. Large amounts of by-products, such as fish brain which contains high level of lipids, are produced with silver carp processing. Fish brain is rich in bioactive lipids which are overwhelmingly effective in preventing cardiovascular diseases. The aim of this study was to elucidate the pharmacological activities of silver carp brain lipids against diseases by inhibiting platelet-activating factor (PAF), suppressing bacterial growth and scavenging free radicals. METHODS: Total lipids (TL) were extracted from silver carp brain and separated into polar lipids (PL) and neutral lipids (NL). The capabilities of the lipid fractions in aggregating washed rabbit platelet or in inhibiting PAF-induced platelet aggregation were tested. Their antibacterial and antiradical activities were studied as well. RESULTS: The lipid fractions exhibited strong inhibitory activities, and the activity of TL was mainly attributed to NL. TL exhibited antibacterial activity towards Staphylococcus aureus, while NL managed to fight against S. aureus and Escherichia coli. PL excelled TL and NL in simultaneously suppressing the growths of Shigella dysenteriae and Salmonella typhi besides those of S. aureus and E. coli. The scavenging effect of PL on 2,2-diphenyl-1-picrylhydrazyl radical was considerably higher than those of TL and NL. CONCLUSION: The present study may help to explain the protective role of fish lipids against diseases and may be responsible for the effectiveness of fish brain in benefiting health. BioMed Central 2013-06-27 /pmc/articles/PMC3717004/ /pubmed/23805935 http://dx.doi.org/10.1186/1476-511X-12-94 Text en Copyright © 2013 Wang et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research
Wang, Caixia
Xia, Wenshui
Xu, Yanshun
Jiang, Qixing
Yin, Shanshan
Yang, Yuwei
Yu, Peipie
Anti-platelet-activating factor, antibacterial, and antiradical activities of lipids extract from silver carp brain
title Anti-platelet-activating factor, antibacterial, and antiradical activities of lipids extract from silver carp brain
title_full Anti-platelet-activating factor, antibacterial, and antiradical activities of lipids extract from silver carp brain
title_fullStr Anti-platelet-activating factor, antibacterial, and antiradical activities of lipids extract from silver carp brain
title_full_unstemmed Anti-platelet-activating factor, antibacterial, and antiradical activities of lipids extract from silver carp brain
title_short Anti-platelet-activating factor, antibacterial, and antiradical activities of lipids extract from silver carp brain
title_sort anti-platelet-activating factor, antibacterial, and antiradical activities of lipids extract from silver carp brain
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3717004/
https://www.ncbi.nlm.nih.gov/pubmed/23805935
http://dx.doi.org/10.1186/1476-511X-12-94
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