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Simplified programming and control of automated radiosynthesizers through unit operations

BACKGROUND: Many automated radiosynthesizers for producing positron emission tomography (PET) probes provide a means for the operator to create custom synthesis programs. The programming interfaces are typically designed with the engineer rather than the radiochemist in mind, requiring lengthy progr...

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Autores principales: Claggett, Shane B, Quinn, Kevin M, Lazari, Mark, Moore, Melissa D, van Dam, R Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3717018/
https://www.ncbi.nlm.nih.gov/pubmed/23855995
http://dx.doi.org/10.1186/2191-219X-3-53
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author Claggett, Shane B
Quinn, Kevin M
Lazari, Mark
Moore, Melissa D
van Dam, R Michael
author_facet Claggett, Shane B
Quinn, Kevin M
Lazari, Mark
Moore, Melissa D
van Dam, R Michael
author_sort Claggett, Shane B
collection PubMed
description BACKGROUND: Many automated radiosynthesizers for producing positron emission tomography (PET) probes provide a means for the operator to create custom synthesis programs. The programming interfaces are typically designed with the engineer rather than the radiochemist in mind, requiring lengthy programs to be created from sequences of low-level, non-intuitive hardware operations. In some cases, the user is even responsible for adding steps to update the graphical representation of the system. In light of these unnecessarily complex approaches, we have created software to perform radiochemistry on the ELIXYS radiosynthesizer with the goal of being intuitive and easy to use. METHODS: Radiochemists were consulted, and a wide range of radiosyntheses were analyzed to determine a comprehensive set of basic chemistry unit operations. Based around these operations, we created a software control system with a client–server architecture. In an attempt to maximize flexibility, the client software was designed to run on a variety of portable multi-touch devices. The software was used to create programs for the synthesis of several (18)F-labeled probes on the ELIXYS radiosynthesizer, with [(18)F]FDG detailed here. To gauge the user-friendliness of the software, program lengths were compared to those from other systems. A small sample group with no prior radiosynthesizer experience was tasked with creating and running a simple protocol. RESULTS: The software was successfully used to synthesize several (18)F-labeled PET probes, including [(18)F]FDG, with synthesis times and yields comparable to literature reports. The resulting programs were significantly shorter and easier to debug than programs from other systems. The sample group of naive users created and ran a simple protocol within a couple of hours, revealing a very short learning curve. The client–server architecture provided reliability, enabling continuity of the synthesis run even if the computer running the client software failed. The architecture enabled a single user to control the hardware while others observed the run in progress or created programs for other probes. CONCLUSIONS: We developed a novel unit operation-based software interface to control automated radiosynthesizers that reduced the program length and complexity and also exhibited a short learning curve. The client–server architecture provided robustness and flexibility.
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spelling pubmed-37170182013-07-22 Simplified programming and control of automated radiosynthesizers through unit operations Claggett, Shane B Quinn, Kevin M Lazari, Mark Moore, Melissa D van Dam, R Michael EJNMMI Res Original Research BACKGROUND: Many automated radiosynthesizers for producing positron emission tomography (PET) probes provide a means for the operator to create custom synthesis programs. The programming interfaces are typically designed with the engineer rather than the radiochemist in mind, requiring lengthy programs to be created from sequences of low-level, non-intuitive hardware operations. In some cases, the user is even responsible for adding steps to update the graphical representation of the system. In light of these unnecessarily complex approaches, we have created software to perform radiochemistry on the ELIXYS radiosynthesizer with the goal of being intuitive and easy to use. METHODS: Radiochemists were consulted, and a wide range of radiosyntheses were analyzed to determine a comprehensive set of basic chemistry unit operations. Based around these operations, we created a software control system with a client–server architecture. In an attempt to maximize flexibility, the client software was designed to run on a variety of portable multi-touch devices. The software was used to create programs for the synthesis of several (18)F-labeled probes on the ELIXYS radiosynthesizer, with [(18)F]FDG detailed here. To gauge the user-friendliness of the software, program lengths were compared to those from other systems. A small sample group with no prior radiosynthesizer experience was tasked with creating and running a simple protocol. RESULTS: The software was successfully used to synthesize several (18)F-labeled PET probes, including [(18)F]FDG, with synthesis times and yields comparable to literature reports. The resulting programs were significantly shorter and easier to debug than programs from other systems. The sample group of naive users created and ran a simple protocol within a couple of hours, revealing a very short learning curve. The client–server architecture provided reliability, enabling continuity of the synthesis run even if the computer running the client software failed. The architecture enabled a single user to control the hardware while others observed the run in progress or created programs for other probes. CONCLUSIONS: We developed a novel unit operation-based software interface to control automated radiosynthesizers that reduced the program length and complexity and also exhibited a short learning curve. The client–server architecture provided robustness and flexibility. Springer 2013-07-15 /pmc/articles/PMC3717018/ /pubmed/23855995 http://dx.doi.org/10.1186/2191-219X-3-53 Text en Copyright ©2013 Claggett et al.; licensee Springer. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Research
Claggett, Shane B
Quinn, Kevin M
Lazari, Mark
Moore, Melissa D
van Dam, R Michael
Simplified programming and control of automated radiosynthesizers through unit operations
title Simplified programming and control of automated radiosynthesizers through unit operations
title_full Simplified programming and control of automated radiosynthesizers through unit operations
title_fullStr Simplified programming and control of automated radiosynthesizers through unit operations
title_full_unstemmed Simplified programming and control of automated radiosynthesizers through unit operations
title_short Simplified programming and control of automated radiosynthesizers through unit operations
title_sort simplified programming and control of automated radiosynthesizers through unit operations
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3717018/
https://www.ncbi.nlm.nih.gov/pubmed/23855995
http://dx.doi.org/10.1186/2191-219X-3-53
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