Importance of leptin signaling and signal transducer and activator of transcription-3 activation in mediating the cardiac hypertrophy associated with obesity

BACKGROUND: The adipokine leptin and its receptor are expressed in the heart, and leptin has been shown to promote cardiomyocyte hypertrophy in vitro. Obesity is associated with hyperleptinemia and hypothalamic leptin resistance as well as an increased risk to develop cardiac hypertrophy and heart f...

Descripción completa

Detalles Bibliográficos
Autores principales: Leifheit-Nestler, Maren, Wagner, Nana-Maria, Gogiraju, Rajinikanth, Didié, Michael, Konstantinides, Stavros, Hasenfuss, Gerd, Schäfer, Katrin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3717024/
https://www.ncbi.nlm.nih.gov/pubmed/23841921
http://dx.doi.org/10.1186/1479-5876-11-170

Ejemplares similares

Ejemplares similares