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Alternate virtual populations elucidate the type I interferon signature predictive of the response to rituximab in rheumatoid arthritis
BACKGROUND: Mechanistic biosimulation can be used in drug development to form testable hypotheses, develop predictions of efficacy before clinical trial results are available, and elucidate clinical response to therapy. However, there is a lack of tools to simultaneously (1) calibrate the prevalence...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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BioMed Central
2013
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3717130/ https://www.ncbi.nlm.nih.gov/pubmed/23841912 http://dx.doi.org/10.1186/1471-2105-14-221 |