Optimization and validation of mitochondria-based functional assay as a useful tool to identify BH3-like molecules selectively targeting anti-apoptotic Bcl-2 proteins

BACKGROUND: Mitochondrial outer membrane permeabilization (MOMP) is a crucial step leading to apoptotic destruction of cancer cells. Bcl-2 family proteins delicately regulate mitochondrial outer membrane integrity through protein-protein interactions, which makes the mitochondrion an ideal cell-free...

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Detalles Bibliográficos
Autores principales: Long, Jianting, Liu, Liu, Nikolovska-Coleska, Zaneta, Shangary, Sanjeev, Yi, Han, Wang, Shenming, Wang, Shaomeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3717276/
https://www.ncbi.nlm.nih.gov/pubmed/23705845
http://dx.doi.org/10.1186/1472-6750-13-45

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3717276/
https://www.ncbi.nlm.nih.gov/pubmed/23705845
http://dx.doi.org/10.1186/1472-6750-13-45

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