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Which Model Better Fits the Role of Aire in the Establishment of Self-Tolerance: The Transcription Model or the Maturation Model?

The discovery of Aire-dependent transcriptional control of many tissue-restricted self-antigen (TRA) genes in thymic epithelial cells in the medulla (medullary thymic epithelial cells, mTECs) has raised the intriguing question of how the single Aire gene can influence the transcription of such a lar...

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Detalles Bibliográficos
Autores principales:	Matsumoto, Mitsuru, Nishikawa, Yumiko, Nishijima, Hitoshi, Morimoto, Junko, Matsumoto, Minoru, Mouri, Yasuhiro
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2013
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3717480/ https://www.ncbi.nlm.nih.gov/pubmed/23885257 http://dx.doi.org/10.3389/fimmu.2013.00210

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