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Current Understanding of the Role of the Brd4 Protein in the Papillomavirus Lifecycle

The Brd4 protein is an epigenetic reader that is central to regulation of cellular transcription and mitotic bookmarking. The transcription and replication proteins of many viruses interact with Brd4. We describe the multiple roles of Brd4 in the papillomavirus lifecycle.

Detalles Bibliográficos
Autores principales: McBride, Alison A., Jang, Moon Kyoo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3717712/
https://www.ncbi.nlm.nih.gov/pubmed/23722886
http://dx.doi.org/10.3390/v5061374
Descripción
Sumario:The Brd4 protein is an epigenetic reader that is central to regulation of cellular transcription and mitotic bookmarking. The transcription and replication proteins of many viruses interact with Brd4. We describe the multiple roles of Brd4 in the papillomavirus lifecycle.