Recurrent targets of aberrant somatic hypermutation in lymphoma

Somatic hypermutation (SHM) in the variable region of immunoglobulin genes (IGV) naturally occurs in a narrow window of B cell development to provide high-affinity antibodies. However, SHM can also aberrantly target proto-oncogenes and cause genome instability. The role of aberrant SHM (aSHM) has be...

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Detalles Bibliográficos
Autores principales: Khodabakhshi, Alireza Hadj, Morin, Ryan D., Fejes, Anthony P., Mungall, Andrew J., Mungall, Karen L., Bolger-Munro, Madison, Johnson, Nathalie A., Connors, Joseph M., Gascoyne, Randy D., Marra, Marco A., Birol, Inanc, Jones, Steven J. M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2012
Materias:
Research Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3717795/
https://www.ncbi.nlm.nih.gov/pubmed/23131835

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