Targeting MCT-1 oncogene inhibits Shc pathway and xenograft tumorigenicity

Overexpression of Shc adaptor proteins is associated with mitogenesis, carcinogenesis and metastasis. Multiple copies in T-cell malignancy 1 (MCT-1) oncoprotein promotes cell proliferation, survival and tumorigenic effects. Our current data show that MCT-1 is a novel regulator of Shc-Ras-MEK-ERK sig...

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Detalles Bibliográficos
Autores principales: Shih, Hung-Ju, Chen, Hsiao-Huei, Chen, Yen-An, Wu, Meng-Hsun, Liou, Gan-Guang, Chang, Wei-Wen, Chen, Linyi, Wang, Lu-Hai, Hsu, Hsin-Ling
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2012
Materias:
Research Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3717801/
https://www.ncbi.nlm.nih.gov/pubmed/23211466

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3717801/
https://www.ncbi.nlm.nih.gov/pubmed/23211466

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