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Targeting HIF2α Translation with Tempol in VHL-Deficient Clear Cell Renal Cell Carcinoma

The tumor suppressor gene, Von Hippel-Lindau (VHL), is frequently mutated in the most common form of kidney cancer, clear cell renal cell carcinoma (CCRCC). In hypoxic conditions, or when there is a VHL mutation, the hypoxia inducible factors, HIF1α and HIF2α, are stabilized and transcribe a panel o...

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Detalles Bibliográficos
Autores principales:	Sourbier, Carole, Srivastava, Gaurav, Ghosh, Manik C., Ghosh, Sanchari, Yang, Youfeng, Gupta, Gopal, DeGraff, William, Krishna, Murali C., Mitchell, James B., Rouault, Tracey A., Linehan, W. Marston
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2012
Materias:	Research Papers
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3717806/ https://www.ncbi.nlm.nih.gov/pubmed/23178531

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