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Somatostatin Receptor Type 2 Antagonism Improves Glucagon Counterregulation in Biobreeding Diabetic Rats

Impaired counterregulation during hypoglycemia in type 1 diabetes (T1D) is partly attributable to inadequate glucagon secretion. Intra-islet somatostatin (SST) suppression of hypoglycemia-stimulated α-cell glucagon release plays an important role. We hypothesized that hypoglycemia can be prevented i...

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Detalles Bibliográficos
Autores principales:	Karimian, Negar, Qin, Tairan, Liang, Tao, Osundiji, Mayowa, Huang, Yachi, Teich, Trevor, Riddell, Michael C., Cattral, Mark S., Coy, David H., Vranic, Mladen, Gaisano, Herbert Y.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Diabetes Association 2013
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3717832/ https://www.ncbi.nlm.nih.gov/pubmed/23630299 http://dx.doi.org/10.2337/db13-0164

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