Cargando…

Potential of Protein Phosphatase Inhibitor 1 As Biomarker of Pancreatic β-Cell Injury In Vitro and In Vivo

There is a need for plasma-based tests that can directly measure the extent of β-cell injury in vivo in patients receiving islet grafts and in animal models. In this study, we propose protein phosphatase 1, regulatory (inhibitor) subunit 1A (PPP1R1A) as a novel biomarker for acute β-cell destruction...

Descripción completa

Detalles Bibliográficos
Autores principales:	Jiang, Lei, Brackeva, Benedicte, Ling, Zhidong, Kramer, Gertjan, Aerts, Johannes M., Schuit, Frans, Keymeulen, Bart, Pipeleers, Daniel, Gorus, Frans, Martens, Geert A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Diabetes Association 2013
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3717856/ https://www.ncbi.nlm.nih.gov/pubmed/23557701 http://dx.doi.org/10.2337/db12-1507

Ejemplares similares

An analytical comparison of three immunoassay platforms for subpicomolar detection of protein biomarker GAD65
por: Costa, Olivier R., et al.
Publicado: (2018)

The MicroRNA Landscape of Acute Beta Cell Destruction in Type 1 Diabetic Recipients of Intraportal Islet Grafts
por: Martens, Geert A., et al.
Publicado: (2021)

Minimal Functional β-Cell Mass in Intraportal Implants That Reduces Glycemic Variability in Type 1 Diabetic Recipients
por: Gillard, Pieter, et al.
Publicado: (2013)

Graves Hyperthyroidism After Stopping Immunosuppressive Therapy in Type 1 Diabetic Islet Cell Recipients With Pretransplant TPO Autoantibodies
por: Gillard, Pieter, et al.
Publicado: (2009)

Correction: Clusters of Conserved Beta Cell Marker Genes for Assessment of Beta Cell Phenotype
por: Martens, Geert A., et al.
Publicado: (2012)

Contribution of Antibodies Against IA-2β and Zinc Transporter 8 to Classification of Diabetes Diagnosed Under 40 Years of Age
por: Vermeulen, Ilse, et al.
Publicado: (2011)

β-Cell Replication Is Increased in Donor Organs From Young Patients After Prolonged Life Support
por: Veld, Peter In't, et al.
Publicado: (2010)

Insulitis in the pancreas of non-diabetic organ donors under age 25 years with multiple circulating autoantibodies against islet cell antigens
por: Smeets, Silke, et al.
Publicado: (2021)

Protein Markers for Insulin-Producing Beta Cells with Higher Glucose Sensitivity
por: Martens, Geert A., et al.
Publicado: (2010)

Quantitative proteomics of rat and human pancreatic beta cells
por: Brackeva, B., et al.
Publicado: (2015)

Zinc transporters and their role in the pancreatic β‐cell
por: Lemaire, Katleen, et al.
Publicado: (2012)

Preexisting Insulin Autoantibodies Predict Efficacy of Otelixizumab in Preserving Residual β-Cell Function in Recent-Onset Type 1 Diabetes
por: Demeester, Simke, et al.
Publicado: (2015)

Differences in Baseline Lymphocyte Counts and Autoreactivity Are Associated With Differences in Outcome of Islet Cell Transplantation in Type 1 Diabetic Patients
por: Hilbrands, Robert, et al.
Publicado: (2009)

Cell Mass Increase Associated with Formation of Glucose‐Controlling β‐Cell Mass in Device‐Encapsulated Implants of hiPS‐Derived Pancreatic Endoderm
por: Robert, Thomas, et al.
Publicado: (2019)

Clusters of Conserved Beta Cell Marker Genes for Assessment of Beta Cell Phenotype
por: Martens, Geert A., et al.
Publicado: (2011)

Correction: Clusters of Conserved Beta Cell Marker Genes for Assessment of Beta Cell Phenotype
por: Martens, Geert A., et al.
Publicado: (2012)

Correction: Clusters of Conserved Beta Cell Marker Genes for Assessment of Beta Cell Phenotype
por: Martens, Geert A., et al.
Publicado: (2012)

Correction: Clusters of Conserved Beta Cell Marker Genes for Assessment of Beta Cell Phenotype
por: Martens, Geert A., et al.
Publicado: (2012)

Beta Cell Count Instead of Beta Cell Mass to Assess and Localize Growth in Beta Cell Population following Pancreatic Duct Ligation in Mice
por: Chintinne, Marie, et al.
Publicado: (2012)

Prediction of Impending Type 1 Diabetes through Automated Dual-Label Measurement of Proinsulin:C-Peptide Ratio
por: Van Dalem, Annelien, et al.
Publicado: (2016)

Correction: Prediction of Impending Type 1 Diabetes through Automated Dual-Label Measurement of Proinsulin:C-Peptide Ratio
por: Van Dalem, Annelien, et al.
Publicado: (2017)

Response to Comment on: Schuit et al. β-Cell–Specific Gene Repression: A Mechanism to Protect Against Inappropriate or Maladjusted Insulin Secretion? Diabetes 2012;61:969–975
por: Schuit, Frans
Publicado: (2012)

miR-375 Targets 3′-Phosphoinositide–Dependent Protein Kinase-1 and Regulates Glucose-Induced Biological Responses in Pancreatic β-Cells
por: El Ouaamari, Abdelfattah, et al.
Publicado: (2008)

CTLA4, SH2B3, and CLEC16A diversely affect the progression of early islet autoimmunity in relatives of Type 1 diabetes patients
por: Vandewalle, Julie, et al.
Publicado: (2023)

Lower beta cell yield from donor pancreases after controlled circulatory death prevented by shortening acirculatory warm ischemia time and by using IGL-1 cold preservation solution
por: De Paep, Diedert L., et al.
Publicado: (2021)

Glucose Regulates Rat Beta Cell Number through Age-Dependent Effects on Beta Cell Survival and Proliferation
por: Assefa, Zerihun, et al.
Publicado: (2014)

Plasticity of Adult Human Pancreatic Duct Cells by Neurogenin3-Mediated Reprogramming
por: Swales, Nathalie, et al.
Publicado: (2012)

Genetic variation at ERBB3/IKZF4 and sexual dimorphism in epitope spreading in single autoantibody-positive relatives
por: Vandewalle, Julie, et al.
Publicado: (2021)

Cellular Islet Autoimmunity Associates with Clinical Outcome of Islet Cell Transplantation
por: Huurman, Volkert A. L., et al.
Publicado: (2008)

Utility of Islet Cell Preparations From Donor Pancreases After Euthanasia
por: De Paep, Diedert L., et al.
Publicado: (2022)

Comparison of Omentum and Subcutis as Implant Sites for Device-Encapsulated Human iPSC-Derived Pancreatic Endoderm in Nude Rats
por: Nijns, Jolien R., et al.
Publicado: (2023)

Serum Cytokines as Biomarkers in Islet Cell Transplantation for Type 1 Diabetes
por: van der Torren, Cornelis R., et al.
Publicado: (2016)

A randomised, single-blind, placebo-controlled, dose-finding safety and tolerability study of the anti-CD3 monoclonal antibody otelixizumab in new-onset type 1 diabetes
por: Keymeulen, Bart, et al.
Publicado: (2020)

Functional Beta Cell Mass from Device-Encapsulated hESC-Derived Pancreatic Endoderm Achieving Metabolic Control
por: Robert, Thomas, et al.
Publicado: (2018)

Susceptibility of Pancreatic Beta Cells to Fatty Acids Is Regulated by LXR/PPARα-Dependent Stearoyl-Coenzyme A Desaturase
por: Hellemans, Karine H., et al.
Publicado: (2009)

Mechanisms of Control of the Free Ca(2+) Concentration in the Endoplasmic Reticulum of Mouse Pancreatic β-Cells: Interplay With Cell Metabolism and [Ca(2+)](c) and Role of SERCA2b and SERCA3
por: Ravier, Magalie A., et al.
Publicado: (2011)

COUP-TFII Controls Mouse Pancreatic β-Cell Mass through GLP-1-β-Catenin Signaling Pathways
por: Boutant, Marie, et al.
Publicado: (2012)

OR03-6 Further Clinical Evaluation of Stem Cell-Derived Islet Replacement Therapy (VC-02) Demonstrates Production of C-Peptide with Improvements in Glycemic Control Parameters in Multiple Patients with Type 1 Diabetes and Hypoglycemia Unawareness
por: Bellin, Melena, et al.
Publicado: (2022)

Ectopic Expression of E2F1 Stimulates β-Cell Proliferation and Function
por: Grouwels, Gael, et al.
Publicado: (2010)

Evidence for Co-Evolution between Human MicroRNAs and Alu-Repeats
por: Lehnert, Stefan, et al.
Publicado: (2009)

Cannot write session to /tmp/vufind_sessions/sess_u1k4hva6b88fnhle87fnmf7c80