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Early Postnatal Nutrition Determines Adult Physical Activity and Energy Expenditure in Female Mice
Decades of research in rodent models has shown that early postnatal overnutrition induces excess adiposity and other components of metabolic syndrome that persist into adulthood. The specific biologic mechanisms explaining the persistence of these effects, however, remain unknown. On postnatal day 1...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Diabetes Association
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3717861/ https://www.ncbi.nlm.nih.gov/pubmed/23545705 http://dx.doi.org/10.2337/db12-1306 |
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author | Li, Ge Kohorst, John J. Zhang, Wenjuan Laritsky, Eleonora Kunde-Ramamoorthy, Govindarajan Baker, Maria S. Fiorotto, Marta L. Waterland, Robert A. |
author_facet | Li, Ge Kohorst, John J. Zhang, Wenjuan Laritsky, Eleonora Kunde-Ramamoorthy, Govindarajan Baker, Maria S. Fiorotto, Marta L. Waterland, Robert A. |
author_sort | Li, Ge |
collection | PubMed |
description | Decades of research in rodent models has shown that early postnatal overnutrition induces excess adiposity and other components of metabolic syndrome that persist into adulthood. The specific biologic mechanisms explaining the persistence of these effects, however, remain unknown. On postnatal day 1 (P1), mice were fostered in control (C) or small litters (SL). SL mice had increased body weight and adiposity at weaning (P21), which persisted to adulthood (P180). Detailed metabolic studies indicated that female adult SL mice have decreased physical activity and energy expenditure but not increased food intake. Genome-scale DNA methylation profiling identified extensive changes in hypothalamic DNA methylation during the suckling period, suggesting that it is a critical period for developmental epigenetics in the mouse hypothalamus. Indeed, SL mice exhibited subtle and sex-specific changes in hypothalamic DNA methylation that persisted from early life to adulthood, providing a potential mechanistic basis for the sustained physiological effects. Expression profiling in adult hypothalamus likewise provided evidence of widespread sex-specific alterations in gene expression. Together, our data indicate that early postnatal overnutrition leads to a reduction in spontaneous physical activity and energy expenditure in females and suggest that early postnatal life is a critical period during which nutrition can affect hypothalamic developmental epigenetics. |
format | Online Article Text |
id | pubmed-3717861 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | American Diabetes Association |
record_format | MEDLINE/PubMed |
spelling | pubmed-37178612014-08-01 Early Postnatal Nutrition Determines Adult Physical Activity and Energy Expenditure in Female Mice Li, Ge Kohorst, John J. Zhang, Wenjuan Laritsky, Eleonora Kunde-Ramamoorthy, Govindarajan Baker, Maria S. Fiorotto, Marta L. Waterland, Robert A. Diabetes Original Research Decades of research in rodent models has shown that early postnatal overnutrition induces excess adiposity and other components of metabolic syndrome that persist into adulthood. The specific biologic mechanisms explaining the persistence of these effects, however, remain unknown. On postnatal day 1 (P1), mice were fostered in control (C) or small litters (SL). SL mice had increased body weight and adiposity at weaning (P21), which persisted to adulthood (P180). Detailed metabolic studies indicated that female adult SL mice have decreased physical activity and energy expenditure but not increased food intake. Genome-scale DNA methylation profiling identified extensive changes in hypothalamic DNA methylation during the suckling period, suggesting that it is a critical period for developmental epigenetics in the mouse hypothalamus. Indeed, SL mice exhibited subtle and sex-specific changes in hypothalamic DNA methylation that persisted from early life to adulthood, providing a potential mechanistic basis for the sustained physiological effects. Expression profiling in adult hypothalamus likewise provided evidence of widespread sex-specific alterations in gene expression. Together, our data indicate that early postnatal overnutrition leads to a reduction in spontaneous physical activity and energy expenditure in females and suggest that early postnatal life is a critical period during which nutrition can affect hypothalamic developmental epigenetics. American Diabetes Association 2013-08 2013-07-17 /pmc/articles/PMC3717861/ /pubmed/23545705 http://dx.doi.org/10.2337/db12-1306 Text en © 2013 by the American Diabetes Association. Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. See http://creativecommons.org/licenses/by-nc-nd/3.0/ for details. |
spellingShingle | Original Research Li, Ge Kohorst, John J. Zhang, Wenjuan Laritsky, Eleonora Kunde-Ramamoorthy, Govindarajan Baker, Maria S. Fiorotto, Marta L. Waterland, Robert A. Early Postnatal Nutrition Determines Adult Physical Activity and Energy Expenditure in Female Mice |
title | Early Postnatal Nutrition Determines Adult Physical Activity and Energy Expenditure in Female Mice |
title_full | Early Postnatal Nutrition Determines Adult Physical Activity and Energy Expenditure in Female Mice |
title_fullStr | Early Postnatal Nutrition Determines Adult Physical Activity and Energy Expenditure in Female Mice |
title_full_unstemmed | Early Postnatal Nutrition Determines Adult Physical Activity and Energy Expenditure in Female Mice |
title_short | Early Postnatal Nutrition Determines Adult Physical Activity and Energy Expenditure in Female Mice |
title_sort | early postnatal nutrition determines adult physical activity and energy expenditure in female mice |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3717861/ https://www.ncbi.nlm.nih.gov/pubmed/23545705 http://dx.doi.org/10.2337/db12-1306 |
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