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Mammalian Target of Rapamycin Regulates Nox4-Mediated Podocyte Depletion in Diabetic Renal Injury

Podocyte apoptosis is a critical mechanism for excessive loss of urinary albumin that eventuates in kidney fibrosis. Pharmacological doses of the mammalian target of rapamycin (mTOR) inhibitor rapamycin reduce albuminuria in diabetes. We explored the hypothesis that mTOR mediates podocyte injury in...

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Detalles Bibliográficos
Autores principales:	Eid, Assaad A., Ford, Bridget M., Bhandary, Basant, de Cassia Cavaglieri, Rita, Block, Karen, Barnes, Jeffrey L., Gorin, Yves, Choudhury, Goutam Ghosh, Abboud, Hanna E.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Diabetes Association 2013
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3717863/ https://www.ncbi.nlm.nih.gov/pubmed/23557706 http://dx.doi.org/10.2337/db12-1504

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