Cargando…

A New Treatment for Hip Osteoarthritis: Clinical Evidence for the Efficacy of Autologous Conditioned Serum

The purpose of the present study was to investigate the effect of intra-articular injections of autologous conditioned serum on human hip osteoarthritis and to test whether a potential treatment effect might be increased by additional injections of steroids and the recombinant interleukin-1 receptor...

Descripción completa

Detalles Bibliográficos
Autores principales: Baltzer, Axel W.A., Ostapczuk, Martin S., Stosch, Daniel, Seidel, Florian, Granrath, Markus
Formato: Online Artículo Texto
Lenguaje:English
Publicado: PAGEPress 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3718237/
https://www.ncbi.nlm.nih.gov/pubmed/23888203
http://dx.doi.org/10.4081/or.2013.e13
_version_ 1782277757353328640
author Baltzer, Axel W.A.
Ostapczuk, Martin S.
Stosch, Daniel
Seidel, Florian
Granrath, Markus
author_facet Baltzer, Axel W.A.
Ostapczuk, Martin S.
Stosch, Daniel
Seidel, Florian
Granrath, Markus
author_sort Baltzer, Axel W.A.
collection PubMed
description The purpose of the present study was to investigate the effect of intra-articular injections of autologous conditioned serum on human hip osteoarthritis and to test whether a potential treatment effect might be increased by additional injections of steroids and the recombinant interleukin-1 receptor antagonist protein anakinra. We compared the effects of autologous conditioned serum 46 hip osteoarthritis patients), autologous conditioned serum+cortisone (56 patients), and autologous conditioned serum+cortisone+recombinant interleukin-1 receptor antagonist protein (17 patients) in a retrospective clinical study by means of the Visual Analogue Scale for pain (pre- vs posttreatment). Over 14 months, treatment resulted in a large, statistically significant improvement for patients in all three groups, independent of the severity of osteoarthritis. Neither cortisone nor cortisone+recombinant interleukin-1 receptor antagonist protein increased the beneficial treatment effect over and above the effect of autologous conditioned serum alone. Autologous conditioned serum successfully reduces pain in hip osteoarthritis. In severe hip osteoarthritis, the sole application of autologous conditioned serum can be even more beneficial than the combination of autologous conditioned serum with steroids.
format Online
Article
Text
id pubmed-3718237
institution National Center for Biotechnology Information
language English
publishDate 2013
publisher PAGEPress
record_format MEDLINE/PubMed
spelling pubmed-37182372013-07-25 A New Treatment for Hip Osteoarthritis: Clinical Evidence for the Efficacy of Autologous Conditioned Serum Baltzer, Axel W.A. Ostapczuk, Martin S. Stosch, Daniel Seidel, Florian Granrath, Markus Orthop Rev (Pavia) Article The purpose of the present study was to investigate the effect of intra-articular injections of autologous conditioned serum on human hip osteoarthritis and to test whether a potential treatment effect might be increased by additional injections of steroids and the recombinant interleukin-1 receptor antagonist protein anakinra. We compared the effects of autologous conditioned serum 46 hip osteoarthritis patients), autologous conditioned serum+cortisone (56 patients), and autologous conditioned serum+cortisone+recombinant interleukin-1 receptor antagonist protein (17 patients) in a retrospective clinical study by means of the Visual Analogue Scale for pain (pre- vs posttreatment). Over 14 months, treatment resulted in a large, statistically significant improvement for patients in all three groups, independent of the severity of osteoarthritis. Neither cortisone nor cortisone+recombinant interleukin-1 receptor antagonist protein increased the beneficial treatment effect over and above the effect of autologous conditioned serum alone. Autologous conditioned serum successfully reduces pain in hip osteoarthritis. In severe hip osteoarthritis, the sole application of autologous conditioned serum can be even more beneficial than the combination of autologous conditioned serum with steroids. PAGEPress 2013-06-14 /pmc/articles/PMC3718237/ /pubmed/23888203 http://dx.doi.org/10.4081/or.2013.e13 Text en ©Copyright A.W.A. Baltzer et al.,
spellingShingle Article
Baltzer, Axel W.A.
Ostapczuk, Martin S.
Stosch, Daniel
Seidel, Florian
Granrath, Markus
A New Treatment for Hip Osteoarthritis: Clinical Evidence for the Efficacy of Autologous Conditioned Serum
title A New Treatment for Hip Osteoarthritis: Clinical Evidence for the Efficacy of Autologous Conditioned Serum
title_full A New Treatment for Hip Osteoarthritis: Clinical Evidence for the Efficacy of Autologous Conditioned Serum
title_fullStr A New Treatment for Hip Osteoarthritis: Clinical Evidence for the Efficacy of Autologous Conditioned Serum
title_full_unstemmed A New Treatment for Hip Osteoarthritis: Clinical Evidence for the Efficacy of Autologous Conditioned Serum
title_short A New Treatment for Hip Osteoarthritis: Clinical Evidence for the Efficacy of Autologous Conditioned Serum
title_sort new treatment for hip osteoarthritis: clinical evidence for the efficacy of autologous conditioned serum
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3718237/
https://www.ncbi.nlm.nih.gov/pubmed/23888203
http://dx.doi.org/10.4081/or.2013.e13
work_keys_str_mv AT baltzeraxelwa anewtreatmentforhiposteoarthritisclinicalevidencefortheefficacyofautologousconditionedserum
AT ostapczukmartins anewtreatmentforhiposteoarthritisclinicalevidencefortheefficacyofautologousconditionedserum
AT stoschdaniel anewtreatmentforhiposteoarthritisclinicalevidencefortheefficacyofautologousconditionedserum
AT seidelflorian anewtreatmentforhiposteoarthritisclinicalevidencefortheefficacyofautologousconditionedserum
AT granrathmarkus anewtreatmentforhiposteoarthritisclinicalevidencefortheefficacyofautologousconditionedserum
AT baltzeraxelwa newtreatmentforhiposteoarthritisclinicalevidencefortheefficacyofautologousconditionedserum
AT ostapczukmartins newtreatmentforhiposteoarthritisclinicalevidencefortheefficacyofautologousconditionedserum
AT stoschdaniel newtreatmentforhiposteoarthritisclinicalevidencefortheefficacyofautologousconditionedserum
AT seidelflorian newtreatmentforhiposteoarthritisclinicalevidencefortheefficacyofautologousconditionedserum
AT granrathmarkus newtreatmentforhiposteoarthritisclinicalevidencefortheefficacyofautologousconditionedserum