Cargando…

A new role for muscle segment homeobox genes in mammalian embryonic diapause

Mammalian embryonic diapause is a phenomenon defined by the temporary arrest in blastocyst growth and metabolic activity within the uterus which synchronously becomes quiescent to blastocyst activation and implantation. This reproductive strategy temporally uncouples conception from parturition unti...

Descripción completa

Detalles Bibliográficos
Autores principales: Cha, Jeeyeon, Sun, Xiaofei, Bartos, Amanda, Fenelon, Jane, Lefèvre, Pavine, Daikoku, Takiko, Shaw, Geoff, Maxson, Robert, Murphy, Bruce D., Renfree, Marilyn B., Dey, Sudhansu K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3718335/
https://www.ncbi.nlm.nih.gov/pubmed/23615030
http://dx.doi.org/10.1098/rsob.130035
_version_ 1782277766873350144
author Cha, Jeeyeon
Sun, Xiaofei
Bartos, Amanda
Fenelon, Jane
Lefèvre, Pavine
Daikoku, Takiko
Shaw, Geoff
Maxson, Robert
Murphy, Bruce D.
Renfree, Marilyn B.
Dey, Sudhansu K.
author_facet Cha, Jeeyeon
Sun, Xiaofei
Bartos, Amanda
Fenelon, Jane
Lefèvre, Pavine
Daikoku, Takiko
Shaw, Geoff
Maxson, Robert
Murphy, Bruce D.
Renfree, Marilyn B.
Dey, Sudhansu K.
author_sort Cha, Jeeyeon
collection PubMed
description Mammalian embryonic diapause is a phenomenon defined by the temporary arrest in blastocyst growth and metabolic activity within the uterus which synchronously becomes quiescent to blastocyst activation and implantation. This reproductive strategy temporally uncouples conception from parturition until environmental or maternal conditions are favourable for the survival of the mother and newborn. The underlying molecular mechanism by which the uterus and embryo temporarily achieve quiescence, maintain blastocyst survival and then resume blastocyst activation with subsequent implantation remains unknown. Here, we show that uterine expression of Msx1 or Msx2, members of an ancient, highly conserved homeobox gene family, persists in three unrelated mammalian species during diapause, followed by rapid downregulation with blastocyst activation and implantation. Mice with uterine inactivation of Msx1 and Msx2 fail to achieve diapause and reactivation. Remarkably, the North American mink and Australian tammar wallaby share similar expression patterns of MSX1 or MSX2 as in mice—it persists during diapause and is rapidly downregulated upon blastocyst activation and implantation. Evidence from mouse studies suggests that the effects of Msx genes in diapause are mediated through Wnt5a, a known transcriptional target of uterine Msx. These studies provide strong evidence that the Msx gene family constitutes a common conserved molecular mediator in the uterus during embryonic diapause to improve female reproductive fitness.
format Online
Article
Text
id pubmed-3718335
institution National Center for Biotechnology Information
language English
publishDate 2013
publisher The Royal Society
record_format MEDLINE/PubMed
spelling pubmed-37183352013-07-29 A new role for muscle segment homeobox genes in mammalian embryonic diapause Cha, Jeeyeon Sun, Xiaofei Bartos, Amanda Fenelon, Jane Lefèvre, Pavine Daikoku, Takiko Shaw, Geoff Maxson, Robert Murphy, Bruce D. Renfree, Marilyn B. Dey, Sudhansu K. Open Biol Research Mammalian embryonic diapause is a phenomenon defined by the temporary arrest in blastocyst growth and metabolic activity within the uterus which synchronously becomes quiescent to blastocyst activation and implantation. This reproductive strategy temporally uncouples conception from parturition until environmental or maternal conditions are favourable for the survival of the mother and newborn. The underlying molecular mechanism by which the uterus and embryo temporarily achieve quiescence, maintain blastocyst survival and then resume blastocyst activation with subsequent implantation remains unknown. Here, we show that uterine expression of Msx1 or Msx2, members of an ancient, highly conserved homeobox gene family, persists in three unrelated mammalian species during diapause, followed by rapid downregulation with blastocyst activation and implantation. Mice with uterine inactivation of Msx1 and Msx2 fail to achieve diapause and reactivation. Remarkably, the North American mink and Australian tammar wallaby share similar expression patterns of MSX1 or MSX2 as in mice—it persists during diapause and is rapidly downregulated upon blastocyst activation and implantation. Evidence from mouse studies suggests that the effects of Msx genes in diapause are mediated through Wnt5a, a known transcriptional target of uterine Msx. These studies provide strong evidence that the Msx gene family constitutes a common conserved molecular mediator in the uterus during embryonic diapause to improve female reproductive fitness. The Royal Society 2013-04 /pmc/articles/PMC3718335/ /pubmed/23615030 http://dx.doi.org/10.1098/rsob.130035 Text en http://creativecommons.org/licenses/by/3.0/ © 2013 The Authors. Published by the Royal Society under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/3.0/, which permits unrestricted use, provided the original author and source are credited.
spellingShingle Research
Cha, Jeeyeon
Sun, Xiaofei
Bartos, Amanda
Fenelon, Jane
Lefèvre, Pavine
Daikoku, Takiko
Shaw, Geoff
Maxson, Robert
Murphy, Bruce D.
Renfree, Marilyn B.
Dey, Sudhansu K.
A new role for muscle segment homeobox genes in mammalian embryonic diapause
title A new role for muscle segment homeobox genes in mammalian embryonic diapause
title_full A new role for muscle segment homeobox genes in mammalian embryonic diapause
title_fullStr A new role for muscle segment homeobox genes in mammalian embryonic diapause
title_full_unstemmed A new role for muscle segment homeobox genes in mammalian embryonic diapause
title_short A new role for muscle segment homeobox genes in mammalian embryonic diapause
title_sort new role for muscle segment homeobox genes in mammalian embryonic diapause
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3718335/
https://www.ncbi.nlm.nih.gov/pubmed/23615030
http://dx.doi.org/10.1098/rsob.130035
work_keys_str_mv AT chajeeyeon anewroleformusclesegmenthomeoboxgenesinmammalianembryonicdiapause
AT sunxiaofei anewroleformusclesegmenthomeoboxgenesinmammalianembryonicdiapause
AT bartosamanda anewroleformusclesegmenthomeoboxgenesinmammalianembryonicdiapause
AT fenelonjane anewroleformusclesegmenthomeoboxgenesinmammalianembryonicdiapause
AT lefevrepavine anewroleformusclesegmenthomeoboxgenesinmammalianembryonicdiapause
AT daikokutakiko anewroleformusclesegmenthomeoboxgenesinmammalianembryonicdiapause
AT shawgeoff anewroleformusclesegmenthomeoboxgenesinmammalianembryonicdiapause
AT maxsonrobert anewroleformusclesegmenthomeoboxgenesinmammalianembryonicdiapause
AT murphybruced anewroleformusclesegmenthomeoboxgenesinmammalianembryonicdiapause
AT renfreemarilynb anewroleformusclesegmenthomeoboxgenesinmammalianembryonicdiapause
AT deysudhansuk anewroleformusclesegmenthomeoboxgenesinmammalianembryonicdiapause
AT chajeeyeon newroleformusclesegmenthomeoboxgenesinmammalianembryonicdiapause
AT sunxiaofei newroleformusclesegmenthomeoboxgenesinmammalianembryonicdiapause
AT bartosamanda newroleformusclesegmenthomeoboxgenesinmammalianembryonicdiapause
AT fenelonjane newroleformusclesegmenthomeoboxgenesinmammalianembryonicdiapause
AT lefevrepavine newroleformusclesegmenthomeoboxgenesinmammalianembryonicdiapause
AT daikokutakiko newroleformusclesegmenthomeoboxgenesinmammalianembryonicdiapause
AT shawgeoff newroleformusclesegmenthomeoboxgenesinmammalianembryonicdiapause
AT maxsonrobert newroleformusclesegmenthomeoboxgenesinmammalianembryonicdiapause
AT murphybruced newroleformusclesegmenthomeoboxgenesinmammalianembryonicdiapause
AT renfreemarilynb newroleformusclesegmenthomeoboxgenesinmammalianembryonicdiapause
AT deysudhansuk newroleformusclesegmenthomeoboxgenesinmammalianembryonicdiapause