Development of an experimental model of infected bone void in the ulna of rabbits

OBJECTIVE: Develop a model that allowed the study of bone regeneration in infection conditions. METHOD: A 15 mm defect was surgically created in the rabbit ulna and inoculated with 5x10(8) colony-forming units (CFU) of S. aureus. Surgical debridement was performed two weeks after and systemic gentam...

Descripción completa

Detalles Bibliográficos
Autores principales: Lemos Azi, Matheus, Kfuri Junior, Mauricio, Martinez, Roberto, Salata, Luis Antonio, Paccola, Cleber Antonio Jansen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Sociedade Brasileira de Ortopedia e Traumatologia Regional de São Paulo 2012
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3718429/
https://www.ncbi.nlm.nih.gov/pubmed/24453593
http://dx.doi.org/10.1590/S1413-78522012000300002
_version_ 1782277776692215808
author Lemos Azi, Matheus
Kfuri Junior, Mauricio
Martinez, Roberto
Salata, Luis Antonio
Paccola, Cleber Antonio Jansen
author_facet Lemos Azi, Matheus
Kfuri Junior, Mauricio
Martinez, Roberto
Salata, Luis Antonio
Paccola, Cleber Antonio Jansen
author_sort Lemos Azi, Matheus
collection PubMed
description OBJECTIVE: Develop a model that allowed the study of bone regeneration in infection conditions. METHOD: A 15 mm defect was surgically created in the rabbit ulna and inoculated with 5x10(8) colony-forming units (CFU) of S. aureus. Surgical debridement was performed two weeks after and systemic gentamicin was administered for four weeks. Animals were followed up to 12 weeks to evaluate infection control and bone regeneration. RESULT: Bone regeneration was inferior to 25% of the defect in radiological and histological analysis. CONCLUSION: Infected bone defect of 15 mm in the rabbit ulna was unable to achieve full regeneration without further treatment. Level of Evidence V, Experimental Study.
format Online
Article
Text
id pubmed-3718429
institution National Center for Biotechnology Information
language English
publishDate 2012
publisher Sociedade Brasileira de Ortopedia e Traumatologia Regional de São Paulo
record_format MEDLINE/PubMed
spelling pubmed-37184292014-01-22 Development of an experimental model of infected bone void in the ulna of rabbits Lemos Azi, Matheus Kfuri Junior, Mauricio Martinez, Roberto Salata, Luis Antonio Paccola, Cleber Antonio Jansen Acta Ortop Bras Original Article OBJECTIVE: Develop a model that allowed the study of bone regeneration in infection conditions. METHOD: A 15 mm defect was surgically created in the rabbit ulna and inoculated with 5x10(8) colony-forming units (CFU) of S. aureus. Surgical debridement was performed two weeks after and systemic gentamicin was administered for four weeks. Animals were followed up to 12 weeks to evaluate infection control and bone regeneration. RESULT: Bone regeneration was inferior to 25% of the defect in radiological and histological analysis. CONCLUSION: Infected bone defect of 15 mm in the rabbit ulna was unable to achieve full regeneration without further treatment. Level of Evidence V, Experimental Study. Sociedade Brasileira de Ortopedia e Traumatologia Regional de São Paulo 2012 /pmc/articles/PMC3718429/ /pubmed/24453593 http://dx.doi.org/10.1590/S1413-78522012000300002 Text en http://creativecommons.org/licenses/by-nc/3.0/ All the content of the journal, except where otherwise noted, is licensed under a Creative Commons License.
spellingShingle Original Article
Lemos Azi, Matheus
Kfuri Junior, Mauricio
Martinez, Roberto
Salata, Luis Antonio
Paccola, Cleber Antonio Jansen
Development of an experimental model of infected bone void in the ulna of rabbits
title Development of an experimental model of infected bone void in the ulna of rabbits
title_full Development of an experimental model of infected bone void in the ulna of rabbits
title_fullStr Development of an experimental model of infected bone void in the ulna of rabbits
title_full_unstemmed Development of an experimental model of infected bone void in the ulna of rabbits
title_short Development of an experimental model of infected bone void in the ulna of rabbits
title_sort development of an experimental model of infected bone void in the ulna of rabbits
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3718429/
https://www.ncbi.nlm.nih.gov/pubmed/24453593
http://dx.doi.org/10.1590/S1413-78522012000300002
work_keys_str_mv AT lemosazimatheus developmentofanexperimentalmodelofinfectedbonevoidintheulnaofrabbits
AT kfurijuniormauricio developmentofanexperimentalmodelofinfectedbonevoidintheulnaofrabbits
AT martinezroberto developmentofanexperimentalmodelofinfectedbonevoidintheulnaofrabbits
AT salataluisantonio developmentofanexperimentalmodelofinfectedbonevoidintheulnaofrabbits
AT paccolacleberantoniojansen developmentofanexperimentalmodelofinfectedbonevoidintheulnaofrabbits

Ejemplares similares