Loss of CARM1 is linked to reduced HuR function in replicative senescence

BACKGROUND: The co-activator-associated arginine methyltransferase 1 (CARM1) catalyzes the methylation of HuR. However, the functional impact of this modification is not fully understood. Here, we investigated the influence of HuR methylation by CARM1 upon the turnover of HuR target mRNAs encoding s...

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Detalles Bibliográficos
Autores principales: Pang, Lijun, Tian, Haiyan, Chang, Na, Yi, Jie, Xue, Lixiang, Jiang, Bin, Gorospe, Myriam, Zhang, Xiaowei, Wang, Wengong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3718661/
https://www.ncbi.nlm.nih.gov/pubmed/23837869
http://dx.doi.org/10.1186/1471-2199-14-15

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