Biological function of Presenilin and its role in AD pathogenesis

Presenilins (PSs) are the catalytic core of γ-secretase complex. However, the mechanism of FAD-associated PS mutations in AD pathogenesis still remains elusive. Here we review the general biology and mechanism of γ-secretase and focus on the catalytic components – presenilins and their biological fu...

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Detalles Bibliográficos
Autores principales: Zhang, Shuting, Zhang, Mingming, Cai, Fang, Song, Weihong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3718700/
https://www.ncbi.nlm.nih.gov/pubmed/23866842
http://dx.doi.org/10.1186/2047-9158-2-15

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