Differential Disruption of EWS-FLI1 Binding by DNA-Binding Agents

Fusion of the EWS gene to FLI1 produces a fusion oncoprotein that drives an aberrant gene expression program responsible for the development of Ewing sarcoma. We used a homogenous proximity assay to screen for compounds that disrupt the binding of EWS-FLI1 to its cognate DNA targets. A number of DNA...

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Detalles Bibliográficos
Autores principales: Chen, Changmin, Wonsey, Diane R., Lemieux, Madeleine E., Kung, Andrew L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3718762/
https://www.ncbi.nlm.nih.gov/pubmed/23894528
http://dx.doi.org/10.1371/journal.pone.0069714

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3718762/
https://www.ncbi.nlm.nih.gov/pubmed/23894528
http://dx.doi.org/10.1371/journal.pone.0069714

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