Increased CD4(+) T Cell Co-Inhibitory Immune Receptor CEACAM1 in Neonatal Sepsis and Soluble-CEACAM1 in Meningococcal Sepsis: A Role in Sepsis-Associated Immune Suppression?

The co-inhibitory immune receptor carcinoembryonic antigen-related cell-adhesion molecule 1 (CEACAM1) and its self-ligand CEACAM1 can suppress T cell function. Suppression of T cell function in sepsis is well documented. Late-onset neonatal sepsis in VLBW-infants was associated with an increased per...

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Autores principales: van der Flier, Michiel, Sharma, Dyana B., Estevão, Silvia, Emonts, Marieke, Rook, Denise, Hazelzet, Jan A., van Goudoever, Johannes B., Hartwig, Nico G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3718779/
https://www.ncbi.nlm.nih.gov/pubmed/23894299
http://dx.doi.org/10.1371/journal.pone.0068294
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author van der Flier, Michiel
Sharma, Dyana B.
Estevão, Silvia
Emonts, Marieke
Rook, Denise
Hazelzet, Jan A.
van Goudoever, Johannes B.
Hartwig, Nico G.
author_facet van der Flier, Michiel
Sharma, Dyana B.
Estevão, Silvia
Emonts, Marieke
Rook, Denise
Hazelzet, Jan A.
van Goudoever, Johannes B.
Hartwig, Nico G.
author_sort van der Flier, Michiel
collection PubMed
description The co-inhibitory immune receptor carcinoembryonic antigen-related cell-adhesion molecule 1 (CEACAM1) and its self-ligand CEACAM1 can suppress T cell function. Suppression of T cell function in sepsis is well documented. Late-onset neonatal sepsis in VLBW-infants was associated with an increased percentage CEACAM1 positive CD4(+) T-cells. Meningococcal septic shock in children was associated with increased serum soluble CEACAM1. In conclusion our data demonstrate increased surface expression of the co-inhibitory immune receptor CEACAM1 in late-onset neonatal sepsis in VLBW-infants, and increased circulating soluble CEACAM1 in children with meningococcal sepsis. Increased T-cell CEACAM1 expression and increased circulating soluble CEACAM1 may contribute to sepsis-associated immune suppression.
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spelling pubmed-37187792013-07-26 Increased CD4(+) T Cell Co-Inhibitory Immune Receptor CEACAM1 in Neonatal Sepsis and Soluble-CEACAM1 in Meningococcal Sepsis: A Role in Sepsis-Associated Immune Suppression? van der Flier, Michiel Sharma, Dyana B. Estevão, Silvia Emonts, Marieke Rook, Denise Hazelzet, Jan A. van Goudoever, Johannes B. Hartwig, Nico G. PLoS One Research Article The co-inhibitory immune receptor carcinoembryonic antigen-related cell-adhesion molecule 1 (CEACAM1) and its self-ligand CEACAM1 can suppress T cell function. Suppression of T cell function in sepsis is well documented. Late-onset neonatal sepsis in VLBW-infants was associated with an increased percentage CEACAM1 positive CD4(+) T-cells. Meningococcal septic shock in children was associated with increased serum soluble CEACAM1. In conclusion our data demonstrate increased surface expression of the co-inhibitory immune receptor CEACAM1 in late-onset neonatal sepsis in VLBW-infants, and increased circulating soluble CEACAM1 in children with meningococcal sepsis. Increased T-cell CEACAM1 expression and increased circulating soluble CEACAM1 may contribute to sepsis-associated immune suppression. Public Library of Science 2013-07-22 /pmc/articles/PMC3718779/ /pubmed/23894299 http://dx.doi.org/10.1371/journal.pone.0068294 Text en © 2013 van der flier et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
van der Flier, Michiel
Sharma, Dyana B.
Estevão, Silvia
Emonts, Marieke
Rook, Denise
Hazelzet, Jan A.
van Goudoever, Johannes B.
Hartwig, Nico G.
Increased CD4(+) T Cell Co-Inhibitory Immune Receptor CEACAM1 in Neonatal Sepsis and Soluble-CEACAM1 in Meningococcal Sepsis: A Role in Sepsis-Associated Immune Suppression?
title Increased CD4(+) T Cell Co-Inhibitory Immune Receptor CEACAM1 in Neonatal Sepsis and Soluble-CEACAM1 in Meningococcal Sepsis: A Role in Sepsis-Associated Immune Suppression?
title_full Increased CD4(+) T Cell Co-Inhibitory Immune Receptor CEACAM1 in Neonatal Sepsis and Soluble-CEACAM1 in Meningococcal Sepsis: A Role in Sepsis-Associated Immune Suppression?
title_fullStr Increased CD4(+) T Cell Co-Inhibitory Immune Receptor CEACAM1 in Neonatal Sepsis and Soluble-CEACAM1 in Meningococcal Sepsis: A Role in Sepsis-Associated Immune Suppression?
title_full_unstemmed Increased CD4(+) T Cell Co-Inhibitory Immune Receptor CEACAM1 in Neonatal Sepsis and Soluble-CEACAM1 in Meningococcal Sepsis: A Role in Sepsis-Associated Immune Suppression?
title_short Increased CD4(+) T Cell Co-Inhibitory Immune Receptor CEACAM1 in Neonatal Sepsis and Soluble-CEACAM1 in Meningococcal Sepsis: A Role in Sepsis-Associated Immune Suppression?
title_sort increased cd4(+) t cell co-inhibitory immune receptor ceacam1 in neonatal sepsis and soluble-ceacam1 in meningococcal sepsis: a role in sepsis-associated immune suppression?
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3718779/
https://www.ncbi.nlm.nih.gov/pubmed/23894299
http://dx.doi.org/10.1371/journal.pone.0068294
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