Cell cycle regulation of Greatwall kinase nuclear localization facilitates mitotic progression

Cell division requires the coordination of critical protein kinases and phosphatases. Greatwall (Gwl) kinase activity inactivates PP2A-B55 at mitotic entry to promote the phosphorylation of cyclin B–Cdk1 substrates, but how Gwl is regulated is poorly understood. We found that the subcellular localiz...

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Detalles Bibliográficos
Autores principales: Wang, Peng, Galan, Jacob A., Normandin, Karine, Bonneil, Éric, Hickson, Gilles R., Roux, Philippe P., Thibault, Pierre, Archambault, Vincent
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2013
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3718974/
https://www.ncbi.nlm.nih.gov/pubmed/23857770
http://dx.doi.org/10.1083/jcb.201211141

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