Validation of tumour models for use in anticancer nanomedicine evaluation: the EPR effect and cathepsin B-mediated drug release rate

PURPOSE: Intravenously (i.v.) administered nanomedicines have the potential for tumour targeting due to the enhanced permeability and retention (EPR) effect, but in vivo tumour models are rarely calibrated with respect to functional vascular permeability and/or mechanisms controlling intratumoural d...

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Detalles Bibliográficos
Autores principales: Duncan, Ruth, Sat-Klopsch, Yee-Nee, Burger, Angelika M., Bibby, Michael C., Fiebig, Heinz H., Sausville, Edward A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2013
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3718995/
https://www.ncbi.nlm.nih.gov/pubmed/23797686
http://dx.doi.org/10.1007/s00280-013-2209-7

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