Resistance in tuberculosis: what do we know and where can we go?

Tuberculosis (TB) has become a worldwide threat, mainly due to the emergence of multidrug-resistant (MDR) and extensively drug-resistant (XDR) strains of Mycobacterium tuberculosis (Mtb). This mini-review is focused on the various mechanisms of resistance to the currently available anti-TB drugs and...

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Detalles Bibliográficos
Autores principales: Green, Keith D., Garneau-Tsodikova, Sylvie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2013
Materias:
Microbiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3719028/
https://www.ncbi.nlm.nih.gov/pubmed/23888158
http://dx.doi.org/10.3389/fmicb.2013.00208
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author Green, Keith D.
Garneau-Tsodikova, Sylvie
author_facet Green, Keith D.
Garneau-Tsodikova, Sylvie
author_sort Green, Keith D.
collection PubMed
description Tuberculosis (TB) has become a worldwide threat, mainly due to the emergence of multidrug-resistant (MDR) and extensively drug-resistant (XDR) strains of Mycobacterium tuberculosis (Mtb). This mini-review is focused on the various mechanisms of resistance to the currently available anti-TB drugs and provides perspective on novel strategies and lead scaffolds/compounds aimed at inhibiting/overcoming these resistance mechanisms.
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spelling pubmed-37190282013-07-25 Resistance in tuberculosis: what do we know and where can we go? Green, Keith D. Garneau-Tsodikova, Sylvie Front Microbiol Microbiology Tuberculosis (TB) has become a worldwide threat, mainly due to the emergence of multidrug-resistant (MDR) and extensively drug-resistant (XDR) strains of Mycobacterium tuberculosis (Mtb). This mini-review is focused on the various mechanisms of resistance to the currently available anti-TB drugs and provides perspective on novel strategies and lead scaffolds/compounds aimed at inhibiting/overcoming these resistance mechanisms. Frontiers Media S.A. 2013-07-23 /pmc/articles/PMC3719028/ /pubmed/23888158 http://dx.doi.org/10.3389/fmicb.2013.00208 Text en Copyright © 2013 Green and Garneau-Tsodikova. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in other forums, provided the original authors and source are credited and subject to any copyright notices concerning any third-party graphics etc.
spellingShingle Microbiology
Green, Keith D.
Garneau-Tsodikova, Sylvie
Resistance in tuberculosis: what do we know and where can we go?
title Resistance in tuberculosis: what do we know and where can we go?
title_full Resistance in tuberculosis: what do we know and where can we go?
title_fullStr Resistance in tuberculosis: what do we know and where can we go?
title_full_unstemmed Resistance in tuberculosis: what do we know and where can we go?
title_short Resistance in tuberculosis: what do we know and where can we go?
title_sort resistance in tuberculosis: what do we know and where can we go?
topic Microbiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3719028/
https://www.ncbi.nlm.nih.gov/pubmed/23888158
http://dx.doi.org/10.3389/fmicb.2013.00208
work_keys_str_mv AT greenkeithd resistanceintuberculosiswhatdoweknowandwherecanwego
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