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Monitoring targeted therapy using dual-energy CT: semi-automatic RECIST plus supplementary functional information by quantifying iodine uptake of melanoma metastases

Aim: Supplementary functional information can contribute to assess response in targeted therapies. The aim of this study was to evaluate semi-automatic RECIST plus iodine uptake (IU) determination in melanoma metastases under BRAF inhibitor (vemurafenib) therapy using dual-energy computed tomography...

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Autores principales: Uhrig, M., Sedlmair, M., Schlemmer, H.P., Hassel, J.C., Ganten, M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: e-Med 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3719051/
https://www.ncbi.nlm.nih.gov/pubmed/23876444
http://dx.doi.org/10.1102/1470-7330.2013.0031
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author Uhrig, M.
Sedlmair, M.
Schlemmer, H.P.
Hassel, J.C.
Ganten, M.
author_facet Uhrig, M.
Sedlmair, M.
Schlemmer, H.P.
Hassel, J.C.
Ganten, M.
author_sort Uhrig, M.
collection PubMed
description Aim: Supplementary functional information can contribute to assess response in targeted therapies. The aim of this study was to evaluate semi-automatic RECIST plus iodine uptake (IU) determination in melanoma metastases under BRAF inhibitor (vemurafenib) therapy using dual-energy computed tomography (DECT). Methods: Nine patients with stage IV melanoma treated with a BRAF inhibitor were included. Contrast-enhanced DECT was performed before and twice after treatment onset. Changes in tumor size were assessed according to RECIST. Quantification of IU (absolute value for total IU (mg) and volume-normalized IU (mg/ml)) was based on semi-automatic tumor volume segmentation. The decrease compared with baseline was calculated. Results: The mean change of RECIST diameter sum per patient was −47% at the first follow-up (FU), −56% at the second FU (P < 0.01). The mean normalized IU per patient was −21% at the first FU (P < 0.2) and −45% at the second FU (P < 0.01). Total IU per patient, combining both normalized IU and volume, showed the most pronounced decrease: −89% at the first FU and −90% at the second FU (P < 0.01). Conclusion: Semi-automatic RECIST plus IU quantification in DECT enables objective, easy and fast parameterization of tumor size and contrast medium uptake, thus providing 2 complementary pieces of information for response monitoring applicable in daily routine.
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spelling pubmed-37190512014-06-13 Monitoring targeted therapy using dual-energy CT: semi-automatic RECIST plus supplementary functional information by quantifying iodine uptake of melanoma metastases Uhrig, M. Sedlmair, M. Schlemmer, H.P. Hassel, J.C. Ganten, M. Cancer Imaging Original Article Aim: Supplementary functional information can contribute to assess response in targeted therapies. The aim of this study was to evaluate semi-automatic RECIST plus iodine uptake (IU) determination in melanoma metastases under BRAF inhibitor (vemurafenib) therapy using dual-energy computed tomography (DECT). Methods: Nine patients with stage IV melanoma treated with a BRAF inhibitor were included. Contrast-enhanced DECT was performed before and twice after treatment onset. Changes in tumor size were assessed according to RECIST. Quantification of IU (absolute value for total IU (mg) and volume-normalized IU (mg/ml)) was based on semi-automatic tumor volume segmentation. The decrease compared with baseline was calculated. Results: The mean change of RECIST diameter sum per patient was −47% at the first follow-up (FU), −56% at the second FU (P < 0.01). The mean normalized IU per patient was −21% at the first FU (P < 0.2) and −45% at the second FU (P < 0.01). Total IU per patient, combining both normalized IU and volume, showed the most pronounced decrease: −89% at the first FU and −90% at the second FU (P < 0.01). Conclusion: Semi-automatic RECIST plus IU quantification in DECT enables objective, easy and fast parameterization of tumor size and contrast medium uptake, thus providing 2 complementary pieces of information for response monitoring applicable in daily routine. e-Med 2013-07-22 /pmc/articles/PMC3719051/ /pubmed/23876444 http://dx.doi.org/10.1102/1470-7330.2013.0031 Text en © 2013 International Cancer Imaging Society
spellingShingle Original Article
Uhrig, M.
Sedlmair, M.
Schlemmer, H.P.
Hassel, J.C.
Ganten, M.
Monitoring targeted therapy using dual-energy CT: semi-automatic RECIST plus supplementary functional information by quantifying iodine uptake of melanoma metastases
title Monitoring targeted therapy using dual-energy CT: semi-automatic RECIST plus supplementary functional information by quantifying iodine uptake of melanoma metastases
title_full Monitoring targeted therapy using dual-energy CT: semi-automatic RECIST plus supplementary functional information by quantifying iodine uptake of melanoma metastases
title_fullStr Monitoring targeted therapy using dual-energy CT: semi-automatic RECIST plus supplementary functional information by quantifying iodine uptake of melanoma metastases
title_full_unstemmed Monitoring targeted therapy using dual-energy CT: semi-automatic RECIST plus supplementary functional information by quantifying iodine uptake of melanoma metastases
title_short Monitoring targeted therapy using dual-energy CT: semi-automatic RECIST plus supplementary functional information by quantifying iodine uptake of melanoma metastases
title_sort monitoring targeted therapy using dual-energy ct: semi-automatic recist plus supplementary functional information by quantifying iodine uptake of melanoma metastases
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3719051/
https://www.ncbi.nlm.nih.gov/pubmed/23876444
http://dx.doi.org/10.1102/1470-7330.2013.0031
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