Recurrent Gastrointestinal Hemorrhage in Treatment with Dasatinib in a Patient Showing SMAD4 Mutation with Acute Lymphoblastic Leukemia Philadelphia Positive and Juvenile Polyposis Hereditary Hemorrhagic Telangiectasia Syndrome

We report a case of a patient affected by juvenile polyposis and hereditary hemorrhagic telangiectasia linked to a SMAD4 mutation who developed acute lymphoblastic leukemia positive for the Philadelphia chromosome translocation and with a complex karyotype. During the treatment with the tyrosine kin...

Descripción completa

Detalles Bibliográficos
Autores principales: Sartor, Chiara, Papayannidis, Cristina, Chiara Abbenante, Maria, Iacobucci, Ilaria, Broccoli, Alessandro, Venturi, Claudia, Testoni, Nicoletta, Ferrari, Anna, Martinelli, Giovanni
Formato: Online Artículo Texto
Lenguaje:English
Publicado: PAGEPress Publications 2013
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3719101/
https://www.ncbi.nlm.nih.gov/pubmed/23888243
http://dx.doi.org/10.4081/hr.2013.e7
Descripción
Sumario:We report a case of a patient affected by juvenile polyposis and hereditary hemorrhagic telangiectasia linked to a SMAD4 mutation who developed acute lymphoblastic leukemia positive for the Philadelphia chromosome translocation and with a complex karyotype. During the treatment with the tyrosine kinase inhibitor dasatinib the patient presented recurrent severe gastrointestinal hemorrhages linked to the genetic background and aggravated by thrombocytopenia.

Ejemplares similares