Recurrent Gastrointestinal Hemorrhage in Treatment with Dasatinib in a Patient Showing SMAD4 Mutation with Acute Lymphoblastic Leukemia Philadelphia Positive and Juvenile Polyposis Hereditary Hemorrhagic Telangiectasia Syndrome

We report a case of a patient affected by juvenile polyposis and hereditary hemorrhagic telangiectasia linked to a SMAD4 mutation who developed acute lymphoblastic leukemia positive for the Philadelphia chromosome translocation and with a complex karyotype. During the treatment with the tyrosine kin...

Descripción completa

Detalles Bibliográficos
Autores principales: Sartor, Chiara, Papayannidis, Cristina, Chiara Abbenante, Maria, Iacobucci, Ilaria, Broccoli, Alessandro, Venturi, Claudia, Testoni, Nicoletta, Ferrari, Anna, Martinelli, Giovanni
Formato: Online Artículo Texto
Lenguaje:English
Publicado: PAGEPress Publications 2013
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3719101/
https://www.ncbi.nlm.nih.gov/pubmed/23888243
http://dx.doi.org/10.4081/hr.2013.e7
_version_ 1782277858732802048
author Sartor, Chiara
Papayannidis, Cristina
Chiara Abbenante, Maria
Iacobucci, Ilaria
Broccoli, Alessandro
Venturi, Claudia
Testoni, Nicoletta
Ferrari, Anna
Martinelli, Giovanni
author_facet Sartor, Chiara
Papayannidis, Cristina
Chiara Abbenante, Maria
Iacobucci, Ilaria
Broccoli, Alessandro
Venturi, Claudia
Testoni, Nicoletta
Ferrari, Anna
Martinelli, Giovanni
author_sort Sartor, Chiara
collection PubMed
description We report a case of a patient affected by juvenile polyposis and hereditary hemorrhagic telangiectasia linked to a SMAD4 mutation who developed acute lymphoblastic leukemia positive for the Philadelphia chromosome translocation and with a complex karyotype. During the treatment with the tyrosine kinase inhibitor dasatinib the patient presented recurrent severe gastrointestinal hemorrhages linked to the genetic background and aggravated by thrombocytopenia.
format Online
Article
Text
id pubmed-3719101
institution National Center for Biotechnology Information
language English
publishDate 2013
publisher PAGEPress Publications
record_format MEDLINE/PubMed
spelling pubmed-37191012013-07-25 Recurrent Gastrointestinal Hemorrhage in Treatment with Dasatinib in a Patient Showing SMAD4 Mutation with Acute Lymphoblastic Leukemia Philadelphia Positive and Juvenile Polyposis Hereditary Hemorrhagic Telangiectasia Syndrome Sartor, Chiara Papayannidis, Cristina Chiara Abbenante, Maria Iacobucci, Ilaria Broccoli, Alessandro Venturi, Claudia Testoni, Nicoletta Ferrari, Anna Martinelli, Giovanni Hematol Rep Case Report We report a case of a patient affected by juvenile polyposis and hereditary hemorrhagic telangiectasia linked to a SMAD4 mutation who developed acute lymphoblastic leukemia positive for the Philadelphia chromosome translocation and with a complex karyotype. During the treatment with the tyrosine kinase inhibitor dasatinib the patient presented recurrent severe gastrointestinal hemorrhages linked to the genetic background and aggravated by thrombocytopenia. PAGEPress Publications 2013-07-03 /pmc/articles/PMC3719101/ /pubmed/23888243 http://dx.doi.org/10.4081/hr.2013.e7 Text en ©Copyright C. Sartor et al.,
spellingShingle Case Report
Sartor, Chiara
Papayannidis, Cristina
Chiara Abbenante, Maria
Iacobucci, Ilaria
Broccoli, Alessandro
Venturi, Claudia
Testoni, Nicoletta
Ferrari, Anna
Martinelli, Giovanni
Recurrent Gastrointestinal Hemorrhage in Treatment with Dasatinib in a Patient Showing SMAD4 Mutation with Acute Lymphoblastic Leukemia Philadelphia Positive and Juvenile Polyposis Hereditary Hemorrhagic Telangiectasia Syndrome
title Recurrent Gastrointestinal Hemorrhage in Treatment with Dasatinib in a Patient Showing SMAD4 Mutation with Acute Lymphoblastic Leukemia Philadelphia Positive and Juvenile Polyposis Hereditary Hemorrhagic Telangiectasia Syndrome
title_full Recurrent Gastrointestinal Hemorrhage in Treatment with Dasatinib in a Patient Showing SMAD4 Mutation with Acute Lymphoblastic Leukemia Philadelphia Positive and Juvenile Polyposis Hereditary Hemorrhagic Telangiectasia Syndrome
title_fullStr Recurrent Gastrointestinal Hemorrhage in Treatment with Dasatinib in a Patient Showing SMAD4 Mutation with Acute Lymphoblastic Leukemia Philadelphia Positive and Juvenile Polyposis Hereditary Hemorrhagic Telangiectasia Syndrome
title_full_unstemmed Recurrent Gastrointestinal Hemorrhage in Treatment with Dasatinib in a Patient Showing SMAD4 Mutation with Acute Lymphoblastic Leukemia Philadelphia Positive and Juvenile Polyposis Hereditary Hemorrhagic Telangiectasia Syndrome
title_short Recurrent Gastrointestinal Hemorrhage in Treatment with Dasatinib in a Patient Showing SMAD4 Mutation with Acute Lymphoblastic Leukemia Philadelphia Positive and Juvenile Polyposis Hereditary Hemorrhagic Telangiectasia Syndrome
title_sort recurrent gastrointestinal hemorrhage in treatment with dasatinib in a patient showing smad4 mutation with acute lymphoblastic leukemia philadelphia positive and juvenile polyposis hereditary hemorrhagic telangiectasia syndrome
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3719101/
https://www.ncbi.nlm.nih.gov/pubmed/23888243
http://dx.doi.org/10.4081/hr.2013.e7
work_keys_str_mv AT sartorchiara recurrentgastrointestinalhemorrhageintreatmentwithdasatinibinapatientshowingsmad4mutationwithacutelymphoblasticleukemiaphiladelphiapositiveandjuvenilepolyposishereditaryhemorrhagictelangiectasiasyndrome
AT papayannidiscristina recurrentgastrointestinalhemorrhageintreatmentwithdasatinibinapatientshowingsmad4mutationwithacutelymphoblasticleukemiaphiladelphiapositiveandjuvenilepolyposishereditaryhemorrhagictelangiectasiasyndrome
AT chiaraabbenantemaria recurrentgastrointestinalhemorrhageintreatmentwithdasatinibinapatientshowingsmad4mutationwithacutelymphoblasticleukemiaphiladelphiapositiveandjuvenilepolyposishereditaryhemorrhagictelangiectasiasyndrome
AT iacobucciilaria recurrentgastrointestinalhemorrhageintreatmentwithdasatinibinapatientshowingsmad4mutationwithacutelymphoblasticleukemiaphiladelphiapositiveandjuvenilepolyposishereditaryhemorrhagictelangiectasiasyndrome
AT broccolialessandro recurrentgastrointestinalhemorrhageintreatmentwithdasatinibinapatientshowingsmad4mutationwithacutelymphoblasticleukemiaphiladelphiapositiveandjuvenilepolyposishereditaryhemorrhagictelangiectasiasyndrome
AT venturiclaudia recurrentgastrointestinalhemorrhageintreatmentwithdasatinibinapatientshowingsmad4mutationwithacutelymphoblasticleukemiaphiladelphiapositiveandjuvenilepolyposishereditaryhemorrhagictelangiectasiasyndrome
AT testoninicoletta recurrentgastrointestinalhemorrhageintreatmentwithdasatinibinapatientshowingsmad4mutationwithacutelymphoblasticleukemiaphiladelphiapositiveandjuvenilepolyposishereditaryhemorrhagictelangiectasiasyndrome
AT ferrarianna recurrentgastrointestinalhemorrhageintreatmentwithdasatinibinapatientshowingsmad4mutationwithacutelymphoblasticleukemiaphiladelphiapositiveandjuvenilepolyposishereditaryhemorrhagictelangiectasiasyndrome
AT martinelligiovanni recurrentgastrointestinalhemorrhageintreatmentwithdasatinibinapatientshowingsmad4mutationwithacutelymphoblasticleukemiaphiladelphiapositiveandjuvenilepolyposishereditaryhemorrhagictelangiectasiasyndrome

Ejemplares similares