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Human Papillomavirusassociated Cancers as Acquired Immunodeficiency Syndrome Defining Illnesses

ABSTRACT: The Centers for Disease Control currently report cervical, vulvar, vaginal, anal and some head and neck cancers as human papillomavirus (HPV)-associated cancers. Only cervical cancer is listed amongst acquired immunodeficiency syndrome (AIDS) defining illnesses. All of these cancers may re...

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Autores principales: Falter II, Keith J., Frimer, Marina, Lavy, Dan, Samuelson, Robert, Shahabi, Shohreh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: PAGEPress Publications 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3719120/
https://www.ncbi.nlm.nih.gov/pubmed/23888225
http://dx.doi.org/10.4081/rt.2013.e25
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author Falter II, Keith J.
Frimer, Marina
Lavy, Dan
Samuelson, Robert
Shahabi, Shohreh
author_facet Falter II, Keith J.
Frimer, Marina
Lavy, Dan
Samuelson, Robert
Shahabi, Shohreh
author_sort Falter II, Keith J.
collection PubMed
description ABSTRACT: The Centers for Disease Control currently report cervical, vulvar, vaginal, anal and some head and neck cancers as human papillomavirus (HPV)-associated cancers. Only cervical cancer is listed amongst acquired immunodeficiency syndrome (AIDS) defining illnesses. All of these cancers may represent progression of the immunocompromised state with the inability to eradicate viral infection. This study reports the case of a 27-year old HIV positive female presenting with a persistent right vulvar exophytic lesion. High-risk HPV analysis and immunostaining for P16 were both positive. A biopsy of the lesion revealed invasive squamous cell carcinoma. The patient underwent neoadjuvant radiation and chemotherapy followed by a radical vulvectomy. During treatment, her CD4 T-lymphocyte count decreased to 120 advancing her condition from HIV to AIDS. This case suggests that all HPV-associated cancers should be included as AIDS defining illnesses.
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spelling pubmed-37191202013-07-25 Human Papillomavirusassociated Cancers as Acquired Immunodeficiency Syndrome Defining Illnesses Falter II, Keith J. Frimer, Marina Lavy, Dan Samuelson, Robert Shahabi, Shohreh Rare Tumors Case Report ABSTRACT: The Centers for Disease Control currently report cervical, vulvar, vaginal, anal and some head and neck cancers as human papillomavirus (HPV)-associated cancers. Only cervical cancer is listed amongst acquired immunodeficiency syndrome (AIDS) defining illnesses. All of these cancers may represent progression of the immunocompromised state with the inability to eradicate viral infection. This study reports the case of a 27-year old HIV positive female presenting with a persistent right vulvar exophytic lesion. High-risk HPV analysis and immunostaining for P16 were both positive. A biopsy of the lesion revealed invasive squamous cell carcinoma. The patient underwent neoadjuvant radiation and chemotherapy followed by a radical vulvectomy. During treatment, her CD4 T-lymphocyte count decreased to 120 advancing her condition from HIV to AIDS. This case suggests that all HPV-associated cancers should be included as AIDS defining illnesses. PAGEPress Publications 2013-06-25 /pmc/articles/PMC3719120/ /pubmed/23888225 http://dx.doi.org/10.4081/rt.2013.e25 Text en ©Copyright K.J. Falter II et al.,
spellingShingle Case Report
Falter II, Keith J.
Frimer, Marina
Lavy, Dan
Samuelson, Robert
Shahabi, Shohreh
Human Papillomavirusassociated Cancers as Acquired Immunodeficiency Syndrome Defining Illnesses
title Human Papillomavirusassociated Cancers as Acquired Immunodeficiency Syndrome Defining Illnesses
title_full Human Papillomavirusassociated Cancers as Acquired Immunodeficiency Syndrome Defining Illnesses
title_fullStr Human Papillomavirusassociated Cancers as Acquired Immunodeficiency Syndrome Defining Illnesses
title_full_unstemmed Human Papillomavirusassociated Cancers as Acquired Immunodeficiency Syndrome Defining Illnesses
title_short Human Papillomavirusassociated Cancers as Acquired Immunodeficiency Syndrome Defining Illnesses
title_sort human papillomavirusassociated cancers as acquired immunodeficiency syndrome defining illnesses
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3719120/
https://www.ncbi.nlm.nih.gov/pubmed/23888225
http://dx.doi.org/10.4081/rt.2013.e25
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