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Anti-ulcer and ulcer healing potentials of Musa sapientum peel extract in the laboratory rodents

BACKGROUND: This study investigated the anti-ulcer and ulcer healing potentials of the methanol extract of Musa sapientum peel in the laboratory rats. MATERIALS AND METHODS: Methanol extract of the peels on Musa sapientum (MEMS) was evaluated for its anti-ulcer using alcohol-induced, aspirin-induced...

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Autores principales: Onasanwo, Samuel Adetunji, Emikpe, Benjamin Obukowho, Ajah, Austin Azubuike, Elufioye, Taiwo Olayemi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3719258/
https://www.ncbi.nlm.nih.gov/pubmed/23900937
http://dx.doi.org/10.4103/0974-8490.112423
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author Onasanwo, Samuel Adetunji
Emikpe, Benjamin Obukowho
Ajah, Austin Azubuike
Elufioye, Taiwo Olayemi
author_facet Onasanwo, Samuel Adetunji
Emikpe, Benjamin Obukowho
Ajah, Austin Azubuike
Elufioye, Taiwo Olayemi
author_sort Onasanwo, Samuel Adetunji
collection PubMed
description BACKGROUND: This study investigated the anti-ulcer and ulcer healing potentials of the methanol extract of Musa sapientum peel in the laboratory rats. MATERIALS AND METHODS: Methanol extract of the peels on Musa sapientum (MEMS) was evaluated for its anti-ulcer using alcohol-induced, aspirin-induced, and pyloric ligation-induced models, and for its ulcer healing employing acetic acid-induced ulcer models in rats. RESULTS: The findings from this experiment showed that MEMS (50, 100 and 200 mg/kg, b.w.) anti-ulcer and ulcer healing activity (P ≤ 0.05) is dose-dependent. Also, MEMS exhibited healing of the ulcer base in all the treated groups when compared with the control group. CONCLUSION: The outcomes of this experiment revealed that the anti-ulcer effect of MEMS may be due to its anti-secretory and cyto-protective activity. The healing of the ulcer base might not be unconnected with basic fibroblast growth factors responsible for epithelial regeneration.
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spelling pubmed-37192582013-07-30 Anti-ulcer and ulcer healing potentials of Musa sapientum peel extract in the laboratory rodents Onasanwo, Samuel Adetunji Emikpe, Benjamin Obukowho Ajah, Austin Azubuike Elufioye, Taiwo Olayemi Pharmacognosy Res Original Article BACKGROUND: This study investigated the anti-ulcer and ulcer healing potentials of the methanol extract of Musa sapientum peel in the laboratory rats. MATERIALS AND METHODS: Methanol extract of the peels on Musa sapientum (MEMS) was evaluated for its anti-ulcer using alcohol-induced, aspirin-induced, and pyloric ligation-induced models, and for its ulcer healing employing acetic acid-induced ulcer models in rats. RESULTS: The findings from this experiment showed that MEMS (50, 100 and 200 mg/kg, b.w.) anti-ulcer and ulcer healing activity (P ≤ 0.05) is dose-dependent. Also, MEMS exhibited healing of the ulcer base in all the treated groups when compared with the control group. CONCLUSION: The outcomes of this experiment revealed that the anti-ulcer effect of MEMS may be due to its anti-secretory and cyto-protective activity. The healing of the ulcer base might not be unconnected with basic fibroblast growth factors responsible for epithelial regeneration. Medknow Publications & Media Pvt Ltd 2013 /pmc/articles/PMC3719258/ /pubmed/23900937 http://dx.doi.org/10.4103/0974-8490.112423 Text en Copyright: © Pharmacognosy Research http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Onasanwo, Samuel Adetunji
Emikpe, Benjamin Obukowho
Ajah, Austin Azubuike
Elufioye, Taiwo Olayemi
Anti-ulcer and ulcer healing potentials of Musa sapientum peel extract in the laboratory rodents
title Anti-ulcer and ulcer healing potentials of Musa sapientum peel extract in the laboratory rodents
title_full Anti-ulcer and ulcer healing potentials of Musa sapientum peel extract in the laboratory rodents
title_fullStr Anti-ulcer and ulcer healing potentials of Musa sapientum peel extract in the laboratory rodents
title_full_unstemmed Anti-ulcer and ulcer healing potentials of Musa sapientum peel extract in the laboratory rodents
title_short Anti-ulcer and ulcer healing potentials of Musa sapientum peel extract in the laboratory rodents
title_sort anti-ulcer and ulcer healing potentials of musa sapientum peel extract in the laboratory rodents
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3719258/
https://www.ncbi.nlm.nih.gov/pubmed/23900937
http://dx.doi.org/10.4103/0974-8490.112423
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