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Anti-ulcer and ulcer healing potentials of Musa sapientum peel extract in the laboratory rodents
BACKGROUND: This study investigated the anti-ulcer and ulcer healing potentials of the methanol extract of Musa sapientum peel in the laboratory rats. MATERIALS AND METHODS: Methanol extract of the peels on Musa sapientum (MEMS) was evaluated for its anti-ulcer using alcohol-induced, aspirin-induced...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Medknow Publications & Media Pvt Ltd
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3719258/ https://www.ncbi.nlm.nih.gov/pubmed/23900937 http://dx.doi.org/10.4103/0974-8490.112423 |
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author | Onasanwo, Samuel Adetunji Emikpe, Benjamin Obukowho Ajah, Austin Azubuike Elufioye, Taiwo Olayemi |
author_facet | Onasanwo, Samuel Adetunji Emikpe, Benjamin Obukowho Ajah, Austin Azubuike Elufioye, Taiwo Olayemi |
author_sort | Onasanwo, Samuel Adetunji |
collection | PubMed |
description | BACKGROUND: This study investigated the anti-ulcer and ulcer healing potentials of the methanol extract of Musa sapientum peel in the laboratory rats. MATERIALS AND METHODS: Methanol extract of the peels on Musa sapientum (MEMS) was evaluated for its anti-ulcer using alcohol-induced, aspirin-induced, and pyloric ligation-induced models, and for its ulcer healing employing acetic acid-induced ulcer models in rats. RESULTS: The findings from this experiment showed that MEMS (50, 100 and 200 mg/kg, b.w.) anti-ulcer and ulcer healing activity (P ≤ 0.05) is dose-dependent. Also, MEMS exhibited healing of the ulcer base in all the treated groups when compared with the control group. CONCLUSION: The outcomes of this experiment revealed that the anti-ulcer effect of MEMS may be due to its anti-secretory and cyto-protective activity. The healing of the ulcer base might not be unconnected with basic fibroblast growth factors responsible for epithelial regeneration. |
format | Online Article Text |
id | pubmed-3719258 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Medknow Publications & Media Pvt Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-37192582013-07-30 Anti-ulcer and ulcer healing potentials of Musa sapientum peel extract in the laboratory rodents Onasanwo, Samuel Adetunji Emikpe, Benjamin Obukowho Ajah, Austin Azubuike Elufioye, Taiwo Olayemi Pharmacognosy Res Original Article BACKGROUND: This study investigated the anti-ulcer and ulcer healing potentials of the methanol extract of Musa sapientum peel in the laboratory rats. MATERIALS AND METHODS: Methanol extract of the peels on Musa sapientum (MEMS) was evaluated for its anti-ulcer using alcohol-induced, aspirin-induced, and pyloric ligation-induced models, and for its ulcer healing employing acetic acid-induced ulcer models in rats. RESULTS: The findings from this experiment showed that MEMS (50, 100 and 200 mg/kg, b.w.) anti-ulcer and ulcer healing activity (P ≤ 0.05) is dose-dependent. Also, MEMS exhibited healing of the ulcer base in all the treated groups when compared with the control group. CONCLUSION: The outcomes of this experiment revealed that the anti-ulcer effect of MEMS may be due to its anti-secretory and cyto-protective activity. The healing of the ulcer base might not be unconnected with basic fibroblast growth factors responsible for epithelial regeneration. Medknow Publications & Media Pvt Ltd 2013 /pmc/articles/PMC3719258/ /pubmed/23900937 http://dx.doi.org/10.4103/0974-8490.112423 Text en Copyright: © Pharmacognosy Research http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Onasanwo, Samuel Adetunji Emikpe, Benjamin Obukowho Ajah, Austin Azubuike Elufioye, Taiwo Olayemi Anti-ulcer and ulcer healing potentials of Musa sapientum peel extract in the laboratory rodents |
title | Anti-ulcer and ulcer healing potentials of Musa sapientum peel extract in the laboratory rodents |
title_full | Anti-ulcer and ulcer healing potentials of Musa sapientum peel extract in the laboratory rodents |
title_fullStr | Anti-ulcer and ulcer healing potentials of Musa sapientum peel extract in the laboratory rodents |
title_full_unstemmed | Anti-ulcer and ulcer healing potentials of Musa sapientum peel extract in the laboratory rodents |
title_short | Anti-ulcer and ulcer healing potentials of Musa sapientum peel extract in the laboratory rodents |
title_sort | anti-ulcer and ulcer healing potentials of musa sapientum peel extract in the laboratory rodents |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3719258/ https://www.ncbi.nlm.nih.gov/pubmed/23900937 http://dx.doi.org/10.4103/0974-8490.112423 |
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