Macroprolactin; A Frequent Cause of Misdiagnosed Hyperprolactinemia in Clinical Practice

INTRODUCTION: Macroprolactin is a significant cause of misdiagnosis, unnecessary investigation, and inappropriate treatment in patients with hyperprolactinemia. Its frequency has not been clearly established due to technical difficulties in identifying it. Most laboratories and clinicians are unawar...

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Autores principales: Vaishya, Richa, Gupta, Rahul, Arora, Sarika
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Avicenna Research Institute 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3719302/
https://www.ncbi.nlm.nih.gov/pubmed/23926484
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author Vaishya, Richa
Gupta, Rahul
Arora, Sarika
author_facet Vaishya, Richa
Gupta, Rahul
Arora, Sarika
author_sort Vaishya, Richa
collection PubMed
description INTRODUCTION: Macroprolactin is a significant cause of misdiagnosis, unnecessary investigation, and inappropriate treatment in patients with hyperprolactinemia. Its frequency has not been clearly established due to technical difficulties in identifying it. Most laboratories and clinicians are unaware of macroprolactin interferences in prolactin assays. MATERIALS AND METHODS: A comprehensive literature search was conducted on the websites of the National Library of Medicine (http://www.ncbl.nlm.nih.gov) and PubMed Central, the US National Library of Medicine's digital archive of life sciences literature (http://www.pubmedcentral.nih.gov/). The data were also looked for in relevant books and journal. RESULTS: Macroprolactin is a non-bioactive prolactin isoform usually composed of a prolactin monomer and an IgG molecule having a prolonged clearance rate similar to that of immunoglobulins. This isoform is clinically non-reactive but it interferes with immunological assays used for the detection of prolactin. CONCLUSION: There is a need to understand and explore the recent progress in the diagnosis and pathophysiology of macroprolactinemia for improving patient care.
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spelling pubmed-37193022013-08-07 Macroprolactin; A Frequent Cause of Misdiagnosed Hyperprolactinemia in Clinical Practice Vaishya, Richa Gupta, Rahul Arora, Sarika J Reprod Infertil Review Article INTRODUCTION: Macroprolactin is a significant cause of misdiagnosis, unnecessary investigation, and inappropriate treatment in patients with hyperprolactinemia. Its frequency has not been clearly established due to technical difficulties in identifying it. Most laboratories and clinicians are unaware of macroprolactin interferences in prolactin assays. MATERIALS AND METHODS: A comprehensive literature search was conducted on the websites of the National Library of Medicine (http://www.ncbl.nlm.nih.gov) and PubMed Central, the US National Library of Medicine's digital archive of life sciences literature (http://www.pubmedcentral.nih.gov/). The data were also looked for in relevant books and journal. RESULTS: Macroprolactin is a non-bioactive prolactin isoform usually composed of a prolactin monomer and an IgG molecule having a prolonged clearance rate similar to that of immunoglobulins. This isoform is clinically non-reactive but it interferes with immunological assays used for the detection of prolactin. CONCLUSION: There is a need to understand and explore the recent progress in the diagnosis and pathophysiology of macroprolactinemia for improving patient care. Avicenna Research Institute 2010 /pmc/articles/PMC3719302/ /pubmed/23926484 Text en Copyright © 2010 Avicenna Research Institute http://creativecommons.org/licenses/by-nc/3.0/ This work is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License which allows users to read, copy, distribute and make derivative works for non-commercial purposes from the material, as long as the author of the original work is cited properly.
spellingShingle Review Article
Vaishya, Richa
Gupta, Rahul
Arora, Sarika
Macroprolactin; A Frequent Cause of Misdiagnosed Hyperprolactinemia in Clinical Practice
title Macroprolactin; A Frequent Cause of Misdiagnosed Hyperprolactinemia in Clinical Practice
title_full Macroprolactin; A Frequent Cause of Misdiagnosed Hyperprolactinemia in Clinical Practice
title_fullStr Macroprolactin; A Frequent Cause of Misdiagnosed Hyperprolactinemia in Clinical Practice
title_full_unstemmed Macroprolactin; A Frequent Cause of Misdiagnosed Hyperprolactinemia in Clinical Practice
title_short Macroprolactin; A Frequent Cause of Misdiagnosed Hyperprolactinemia in Clinical Practice
title_sort macroprolactin; a frequent cause of misdiagnosed hyperprolactinemia in clinical practice
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3719302/
https://www.ncbi.nlm.nih.gov/pubmed/23926484
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