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Effects of Varicocelectomy on Anti-sperm Antibody in Patients with Varicocele

BACKGROUND: Anti-sperm antibody (ASA) can decrease sperm motility and, therefore, it is a cause of male infertility. The aim of this study was to evaluate the effects of varicocelectomy on anti-sperm antibody in patients with varicocele. METHODS: This observational study was conducted on 90 patients...

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Autores principales: Bonyadi, Mohammad Reza, Madaen, Sayyed Kazem, Saghafi, Maryam
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Avicenna Research Institute 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3719315/
https://www.ncbi.nlm.nih.gov/pubmed/23926568
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author Bonyadi, Mohammad Reza
Madaen, Sayyed Kazem
Saghafi, Maryam
author_facet Bonyadi, Mohammad Reza
Madaen, Sayyed Kazem
Saghafi, Maryam
author_sort Bonyadi, Mohammad Reza
collection PubMed
description BACKGROUND: Anti-sperm antibody (ASA) can decrease sperm motility and, therefore, it is a cause of male infertility. The aim of this study was to evaluate the effects of varicocelectomy on anti-sperm antibody in patients with varicocele. METHODS: This observational study was conducted on 90 patients with varicocele at Sina and Imam Khomeini hospitals during 2006 to 2009. All varicocelectomy candidates were selected for ASA assessment both in semen and serum before and after surgery. ASA level was measured using a direct method for semen and an indirect method of Sperm MAR test, for serum. Paired t-test and McNemar's test were used for data analysis, and p<0.05 was considered statistically significant. RESULTS: ASA level in semen was 13.7% before, and 15.7% after three month of varicocelectomy (p=0.881). Serum level of ASA before and after surgery were 13.6% and 21.7%, respectively (p=0.033). Three parameters including sperm count, motility and morphology showed recovery following, varicocelectomy, but only the difference in sperm motility was significant (p<0.05). CONCLUSION: This study showed that varicocelectomy has no effect on semen ASA. Although serum antibody has been shown to increase after varicocelectomy but sperm motility will improve. Varicocelectomy seems to have a beneficial effect on semen parameters in infertile men with varicocele.
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spelling pubmed-37193152013-08-07 Effects of Varicocelectomy on Anti-sperm Antibody in Patients with Varicocele Bonyadi, Mohammad Reza Madaen, Sayyed Kazem Saghafi, Maryam J Reprod Infertil Original Article BACKGROUND: Anti-sperm antibody (ASA) can decrease sperm motility and, therefore, it is a cause of male infertility. The aim of this study was to evaluate the effects of varicocelectomy on anti-sperm antibody in patients with varicocele. METHODS: This observational study was conducted on 90 patients with varicocele at Sina and Imam Khomeini hospitals during 2006 to 2009. All varicocelectomy candidates were selected for ASA assessment both in semen and serum before and after surgery. ASA level was measured using a direct method for semen and an indirect method of Sperm MAR test, for serum. Paired t-test and McNemar's test were used for data analysis, and p<0.05 was considered statistically significant. RESULTS: ASA level in semen was 13.7% before, and 15.7% after three month of varicocelectomy (p=0.881). Serum level of ASA before and after surgery were 13.6% and 21.7%, respectively (p=0.033). Three parameters including sperm count, motility and morphology showed recovery following, varicocelectomy, but only the difference in sperm motility was significant (p<0.05). CONCLUSION: This study showed that varicocelectomy has no effect on semen ASA. Although serum antibody has been shown to increase after varicocelectomy but sperm motility will improve. Varicocelectomy seems to have a beneficial effect on semen parameters in infertile men with varicocele. Avicenna Research Institute 2013 /pmc/articles/PMC3719315/ /pubmed/23926568 Text en Copyright © 2013 Avicenna Research Institute http://creativecommons.org/licenses/by-nc/3.0/ This work is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License which allows users to read, copy, distribute and make derivative works for non-commercial purposes from the material, as long as the author of the original work is cited properly.
spellingShingle Original Article
Bonyadi, Mohammad Reza
Madaen, Sayyed Kazem
Saghafi, Maryam
Effects of Varicocelectomy on Anti-sperm Antibody in Patients with Varicocele
title Effects of Varicocelectomy on Anti-sperm Antibody in Patients with Varicocele
title_full Effects of Varicocelectomy on Anti-sperm Antibody in Patients with Varicocele
title_fullStr Effects of Varicocelectomy on Anti-sperm Antibody in Patients with Varicocele
title_full_unstemmed Effects of Varicocelectomy on Anti-sperm Antibody in Patients with Varicocele
title_short Effects of Varicocelectomy on Anti-sperm Antibody in Patients with Varicocele
title_sort effects of varicocelectomy on anti-sperm antibody in patients with varicocele
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3719315/
https://www.ncbi.nlm.nih.gov/pubmed/23926568
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