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Current Chlamydia trachomatis Infection, A Major Cause of Infertility
BACKGROUND: In India, the impact of current Chlamydia trachomatis (C. trachomatis) in reproductive health remains a neglected area of investigation. The present study evaluates if current Chlamydia infection is associated with any clinical complication that needs the attention of clinical investigat...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Avicenna Research Institute
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3719340/ https://www.ncbi.nlm.nih.gov/pubmed/23926547 |
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author | Mania-Pramanik, Jayanti Kerkar, Shilpa Sonawane, Shobha Mehta, Pratibha Salvi, Vinita |
author_facet | Mania-Pramanik, Jayanti Kerkar, Shilpa Sonawane, Shobha Mehta, Pratibha Salvi, Vinita |
author_sort | Mania-Pramanik, Jayanti |
collection | PubMed |
description | BACKGROUND: In India, the impact of current Chlamydia trachomatis (C. trachomatis) in reproductive health remains a neglected area of investigation. The present study evaluates if current Chlamydia infection is associated with any clinical complication that needs the attention of clinical investigators. METHODS: In this cross-sectional study, we enrolled 896 women attending the Gynecology Out Patient for the detection of C. trachomatis infection. Polymerase chain reaction was used to diagnose current C. trachomatis infection and ELISA for past infections. Bacterial vaginosis, Candida and Trichomonas were screened. The results of symptomatic and asymptomatic groups were compared. The data was analyzed using Epi Info version 6 and “Z” test. A probability value of p≤0.05 was considered as significant.. RESULTS: Statistical analysis revealed significant association between current C. trachomatis infection with infertility when comparing infected fertile (18.6% vs. 9.4%, odds ratio: 2.19, p<0.0005) and uninfected infertile women (45.6% vs. 27.3%, odds ratio: 2.24, p<0.0001). Average infection rate was 12.1%, highest in women with infertility (18.6%) or with ectopic pregnancy (25%). Significant proportions of infected women with infertility (p<0.01) or with recent pregnancy (p<0.001) were asymptomatic. Follow up of infected women who became negative after treatment [28 women from infertility group and 9 women with recurrent spontaneous abortion (RSA)] revealed live birth in 8 (21.6%) women within one year, 4 with infertility and 4 with RSA. CONCLUSION: Study findings suggest association between current C. trachomatis infection and infertility. Absence of signs and symptoms associated with this infection highlights its diagnosis in women with a history of infertility and RSA for their better management, as revealed by live births with one year of follow up. |
format | Online Article Text |
id | pubmed-3719340 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Avicenna Research Institute |
record_format | MEDLINE/PubMed |
spelling | pubmed-37193402013-08-07 Current Chlamydia trachomatis Infection, A Major Cause of Infertility Mania-Pramanik, Jayanti Kerkar, Shilpa Sonawane, Shobha Mehta, Pratibha Salvi, Vinita J Reprod Infertil Original Article BACKGROUND: In India, the impact of current Chlamydia trachomatis (C. trachomatis) in reproductive health remains a neglected area of investigation. The present study evaluates if current Chlamydia infection is associated with any clinical complication that needs the attention of clinical investigators. METHODS: In this cross-sectional study, we enrolled 896 women attending the Gynecology Out Patient for the detection of C. trachomatis infection. Polymerase chain reaction was used to diagnose current C. trachomatis infection and ELISA for past infections. Bacterial vaginosis, Candida and Trichomonas were screened. The results of symptomatic and asymptomatic groups were compared. The data was analyzed using Epi Info version 6 and “Z” test. A probability value of p≤0.05 was considered as significant.. RESULTS: Statistical analysis revealed significant association between current C. trachomatis infection with infertility when comparing infected fertile (18.6% vs. 9.4%, odds ratio: 2.19, p<0.0005) and uninfected infertile women (45.6% vs. 27.3%, odds ratio: 2.24, p<0.0001). Average infection rate was 12.1%, highest in women with infertility (18.6%) or with ectopic pregnancy (25%). Significant proportions of infected women with infertility (p<0.01) or with recent pregnancy (p<0.001) were asymptomatic. Follow up of infected women who became negative after treatment [28 women from infertility group and 9 women with recurrent spontaneous abortion (RSA)] revealed live birth in 8 (21.6%) women within one year, 4 with infertility and 4 with RSA. CONCLUSION: Study findings suggest association between current C. trachomatis infection and infertility. Absence of signs and symptoms associated with this infection highlights its diagnosis in women with a history of infertility and RSA for their better management, as revealed by live births with one year of follow up. Avicenna Research Institute 2012 /pmc/articles/PMC3719340/ /pubmed/23926547 Text en Copyright © 2012 Avicenna Research Institute http://creativecommons.org/licenses/by-nc/3.0/ This work is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License which allows users to read, copy, distribute and make derivative works for non-commercial purposes from the material, as long as the author of the original work is cited properly. |
spellingShingle | Original Article Mania-Pramanik, Jayanti Kerkar, Shilpa Sonawane, Shobha Mehta, Pratibha Salvi, Vinita Current Chlamydia trachomatis Infection, A Major Cause of Infertility |
title | Current Chlamydia trachomatis Infection, A Major Cause of Infertility |
title_full | Current Chlamydia trachomatis Infection, A Major Cause of Infertility |
title_fullStr | Current Chlamydia trachomatis Infection, A Major Cause of Infertility |
title_full_unstemmed | Current Chlamydia trachomatis Infection, A Major Cause of Infertility |
title_short | Current Chlamydia trachomatis Infection, A Major Cause of Infertility |
title_sort | current chlamydia trachomatis infection, a major cause of infertility |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3719340/ https://www.ncbi.nlm.nih.gov/pubmed/23926547 |
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