Use of Vitek 2 Antimicrobial Susceptibility Profile To Identify mecC in Methicillin-Resistant Staphylococcus aureus

The emergence of mecC methicillin-resistant Staphylococcus aureus (MRSA) poses a diagnostic challenge for clinical microbiology laboratories. Using the Vitek 2 system, we tested a panel of 896 Staphylococcus aureus isolates and found that an oxacillin-sensitive/cefoxitin-resistant profile had a sens...

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Detalles Bibliográficos
Autores principales: Cartwright, Edward J. P., Paterson, Gavin K., Raven, Kathy E., Harrison, Ewan M., Gouliouris, Theodore, Kearns, Angela, Pichon, Bruno, Edwards, Giles, Skov, Robert L., Larsen, Anders R., Holmes, Mark A., Parkhill, Julian, Peacock, Sharon J., Török, M. Estée
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2013
Materias:
Bacteriology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3719650/
https://www.ncbi.nlm.nih.gov/pubmed/23720794
http://dx.doi.org/10.1128/JCM.00847-13
Descripción
Sumario:The emergence of mecC methicillin-resistant Staphylococcus aureus (MRSA) poses a diagnostic challenge for clinical microbiology laboratories. Using the Vitek 2 system, we tested a panel of 896 Staphylococcus aureus isolates and found that an oxacillin-sensitive/cefoxitin-resistant profile had a sensitivity of 88.7% and a specificity of 99.5% for the identification of mecC MRSA isolates. The presence of the mecC gene, determined by bacterial whole-genome sequencing, was used as the gold standard. This profile could provide a zero-cost screening method for identification of mecC-positive MRSA strains.

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