Population-Level Antibody Estimates to Novel Influenza A/H7N9

There are no contemporary data available describing human immunity to novel influenza A/H7N9. Using 1723 prospectively collected serum samples in southern Vietnam, we tested for antibodies to 5 avian influenza virus antigens, using a protein microarray. General-population antibody titers against sub...

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Autores principales: Boni, Maciej F., Chau, Nguyen Van Vinh, Dong, Nguyen, Todd, Stacy, Nhat, Nguyen Thi Duy, de Bruin, Erwin, van Beek, Janko, Hien, Nguyen Tran, Simmons, Cameron P., Farrar, Jeremy, Koopmans, Marion
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2013
Materias:
Major Articles and Brief Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3719906/
https://www.ncbi.nlm.nih.gov/pubmed/23687225
http://dx.doi.org/10.1093/infdis/jit224
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author Boni, Maciej F.
Chau, Nguyen Van Vinh
Dong, Nguyen
Todd, Stacy
Nhat, Nguyen Thi Duy
de Bruin, Erwin
van Beek, Janko
Hien, Nguyen Tran
Simmons, Cameron P.
Farrar, Jeremy
Koopmans, Marion
author_facet Boni, Maciej F.
Chau, Nguyen Van Vinh
Dong, Nguyen
Todd, Stacy
Nhat, Nguyen Thi Duy
de Bruin, Erwin
van Beek, Janko
Hien, Nguyen Tran
Simmons, Cameron P.
Farrar, Jeremy
Koopmans, Marion
author_sort Boni, Maciej F.
collection PubMed
description There are no contemporary data available describing human immunity to novel influenza A/H7N9. Using 1723 prospectively collected serum samples in southern Vietnam, we tested for antibodies to 5 avian influenza virus antigens, using a protein microarray. General-population antibody titers against subtype H7 virus are higher than antibody titers against subtype H5 and lower than titers against H9. The highest titers were observed for human influenza virus subtypes. Titers to avian influenza virus antigens increased with age and with geometric mean antibody titer to human influenza virus antigens. There were no titer differences between the urban and the rural location in our study.
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spelling pubmed-37199062013-07-23 Population-Level Antibody Estimates to Novel Influenza A/H7N9 Boni, Maciej F. Chau, Nguyen Van Vinh Dong, Nguyen Todd, Stacy Nhat, Nguyen Thi Duy de Bruin, Erwin van Beek, Janko Hien, Nguyen Tran Simmons, Cameron P. Farrar, Jeremy Koopmans, Marion J Infect Dis Major Articles and Brief Reports There are no contemporary data available describing human immunity to novel influenza A/H7N9. Using 1723 prospectively collected serum samples in southern Vietnam, we tested for antibodies to 5 avian influenza virus antigens, using a protein microarray. General-population antibody titers against subtype H7 virus are higher than antibody titers against subtype H5 and lower than titers against H9. The highest titers were observed for human influenza virus subtypes. Titers to avian influenza virus antigens increased with age and with geometric mean antibody titer to human influenza virus antigens. There were no titer differences between the urban and the rural location in our study. Oxford University Press 2013-08-15 2013-05-17 /pmc/articles/PMC3719906/ /pubmed/23687225 http://dx.doi.org/10.1093/infdis/jit224 Text en © The Author 2013. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (http://creativecommons.org/licenses/by-nc-nd/3.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work properly cited. For commercial re-use, please contact journals.permissions@oup.com.
spellingShingle Major Articles and Brief Reports
Boni, Maciej F.
Chau, Nguyen Van Vinh
Dong, Nguyen
Todd, Stacy
Nhat, Nguyen Thi Duy
de Bruin, Erwin
van Beek, Janko
Hien, Nguyen Tran
Simmons, Cameron P.
Farrar, Jeremy
Koopmans, Marion
Population-Level Antibody Estimates to Novel Influenza A/H7N9
title Population-Level Antibody Estimates to Novel Influenza A/H7N9
title_full Population-Level Antibody Estimates to Novel Influenza A/H7N9
title_fullStr Population-Level Antibody Estimates to Novel Influenza A/H7N9
title_full_unstemmed Population-Level Antibody Estimates to Novel Influenza A/H7N9
title_short Population-Level Antibody Estimates to Novel Influenza A/H7N9
title_sort population-level antibody estimates to novel influenza a/h7n9
topic Major Articles and Brief Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3719906/
https://www.ncbi.nlm.nih.gov/pubmed/23687225
http://dx.doi.org/10.1093/infdis/jit224
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