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Chitosan against cutaneous pathogens

Propionibacterium acnes and Staphylococcus aureus are cutaneous pathogens that have become increasingly resistant to antibiotics. We sought to determine if chitosan, a polymer of deacetylated chitin, could be used as a potential treatment against these bacteria. We found that higher molecular weight...

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Detalles Bibliográficos
Autores principales: Champer, Jackson, Patel, Julie, Fernando, Nathalie, Salehi, Elaheh, Wong, Victoria, Kim, Jenny
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3720194/
https://www.ncbi.nlm.nih.gov/pubmed/23829873
http://dx.doi.org/10.1186/2191-0855-3-37
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author Champer, Jackson
Patel, Julie
Fernando, Nathalie
Salehi, Elaheh
Wong, Victoria
Kim, Jenny
author_facet Champer, Jackson
Patel, Julie
Fernando, Nathalie
Salehi, Elaheh
Wong, Victoria
Kim, Jenny
author_sort Champer, Jackson
collection PubMed
description Propionibacterium acnes and Staphylococcus aureus are cutaneous pathogens that have become increasingly resistant to antibiotics. We sought to determine if chitosan, a polymer of deacetylated chitin, could be used as a potential treatment against these bacteria. We found that higher molecular weight chitosan had superior antimicrobial properties compared to lower molecular weights, and that this activity occurred in a pH dependent manner. Electron and fluorescence microscopy revealed that chitosan forms aggregates and binds to the surface of bacteria, causing shrinkage of the bacterial membrane from the cell wall. Of special relevance, clinical isolates of P. acnes were vulnerable to chitosan, which could be combined with benzoyl peroxide for additive antibacterial effect. Chitosan also demonstrated significantly less cytotoxicity to monocytes than benzoyl peroxide. Overall, chitosan demonstrates many promising qualities for treatment of cutaneous pathogens.
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spelling pubmed-37201942013-07-24 Chitosan against cutaneous pathogens Champer, Jackson Patel, Julie Fernando, Nathalie Salehi, Elaheh Wong, Victoria Kim, Jenny AMB Express Original Article Propionibacterium acnes and Staphylococcus aureus are cutaneous pathogens that have become increasingly resistant to antibiotics. We sought to determine if chitosan, a polymer of deacetylated chitin, could be used as a potential treatment against these bacteria. We found that higher molecular weight chitosan had superior antimicrobial properties compared to lower molecular weights, and that this activity occurred in a pH dependent manner. Electron and fluorescence microscopy revealed that chitosan forms aggregates and binds to the surface of bacteria, causing shrinkage of the bacterial membrane from the cell wall. Of special relevance, clinical isolates of P. acnes were vulnerable to chitosan, which could be combined with benzoyl peroxide for additive antibacterial effect. Chitosan also demonstrated significantly less cytotoxicity to monocytes than benzoyl peroxide. Overall, chitosan demonstrates many promising qualities for treatment of cutaneous pathogens. Springer 2013-07-06 /pmc/articles/PMC3720194/ /pubmed/23829873 http://dx.doi.org/10.1186/2191-0855-3-37 Text en Copyright ©2013 Champer et al.; licensee Springer. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Champer, Jackson
Patel, Julie
Fernando, Nathalie
Salehi, Elaheh
Wong, Victoria
Kim, Jenny
Chitosan against cutaneous pathogens
title Chitosan against cutaneous pathogens
title_full Chitosan against cutaneous pathogens
title_fullStr Chitosan against cutaneous pathogens
title_full_unstemmed Chitosan against cutaneous pathogens
title_short Chitosan against cutaneous pathogens
title_sort chitosan against cutaneous pathogens
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3720194/
https://www.ncbi.nlm.nih.gov/pubmed/23829873
http://dx.doi.org/10.1186/2191-0855-3-37
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