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Chitosan against cutaneous pathogens
Propionibacterium acnes and Staphylococcus aureus are cutaneous pathogens that have become increasingly resistant to antibiotics. We sought to determine if chitosan, a polymer of deacetylated chitin, could be used as a potential treatment against these bacteria. We found that higher molecular weight...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3720194/ https://www.ncbi.nlm.nih.gov/pubmed/23829873 http://dx.doi.org/10.1186/2191-0855-3-37 |
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author | Champer, Jackson Patel, Julie Fernando, Nathalie Salehi, Elaheh Wong, Victoria Kim, Jenny |
author_facet | Champer, Jackson Patel, Julie Fernando, Nathalie Salehi, Elaheh Wong, Victoria Kim, Jenny |
author_sort | Champer, Jackson |
collection | PubMed |
description | Propionibacterium acnes and Staphylococcus aureus are cutaneous pathogens that have become increasingly resistant to antibiotics. We sought to determine if chitosan, a polymer of deacetylated chitin, could be used as a potential treatment against these bacteria. We found that higher molecular weight chitosan had superior antimicrobial properties compared to lower molecular weights, and that this activity occurred in a pH dependent manner. Electron and fluorescence microscopy revealed that chitosan forms aggregates and binds to the surface of bacteria, causing shrinkage of the bacterial membrane from the cell wall. Of special relevance, clinical isolates of P. acnes were vulnerable to chitosan, which could be combined with benzoyl peroxide for additive antibacterial effect. Chitosan also demonstrated significantly less cytotoxicity to monocytes than benzoyl peroxide. Overall, chitosan demonstrates many promising qualities for treatment of cutaneous pathogens. |
format | Online Article Text |
id | pubmed-3720194 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Springer |
record_format | MEDLINE/PubMed |
spelling | pubmed-37201942013-07-24 Chitosan against cutaneous pathogens Champer, Jackson Patel, Julie Fernando, Nathalie Salehi, Elaheh Wong, Victoria Kim, Jenny AMB Express Original Article Propionibacterium acnes and Staphylococcus aureus are cutaneous pathogens that have become increasingly resistant to antibiotics. We sought to determine if chitosan, a polymer of deacetylated chitin, could be used as a potential treatment against these bacteria. We found that higher molecular weight chitosan had superior antimicrobial properties compared to lower molecular weights, and that this activity occurred in a pH dependent manner. Electron and fluorescence microscopy revealed that chitosan forms aggregates and binds to the surface of bacteria, causing shrinkage of the bacterial membrane from the cell wall. Of special relevance, clinical isolates of P. acnes were vulnerable to chitosan, which could be combined with benzoyl peroxide for additive antibacterial effect. Chitosan also demonstrated significantly less cytotoxicity to monocytes than benzoyl peroxide. Overall, chitosan demonstrates many promising qualities for treatment of cutaneous pathogens. Springer 2013-07-06 /pmc/articles/PMC3720194/ /pubmed/23829873 http://dx.doi.org/10.1186/2191-0855-3-37 Text en Copyright ©2013 Champer et al.; licensee Springer. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Champer, Jackson Patel, Julie Fernando, Nathalie Salehi, Elaheh Wong, Victoria Kim, Jenny Chitosan against cutaneous pathogens |
title | Chitosan against cutaneous pathogens |
title_full | Chitosan against cutaneous pathogens |
title_fullStr | Chitosan against cutaneous pathogens |
title_full_unstemmed | Chitosan against cutaneous pathogens |
title_short | Chitosan against cutaneous pathogens |
title_sort | chitosan against cutaneous pathogens |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3720194/ https://www.ncbi.nlm.nih.gov/pubmed/23829873 http://dx.doi.org/10.1186/2191-0855-3-37 |
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