Threats to Validity in the Design and Conduct of Preclinical Efficacy Studies: A Systematic Review of Guidelines for In Vivo Animal Experiments

BACKGROUND: The vast majority of medical interventions introduced into clinical development prove unsafe or ineffective. One prominent explanation for the dismal success rate is flawed preclinical research. We conducted a systematic review of preclinical research guidelines and organized recommendat...

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Detalles Bibliográficos
Autores principales: Henderson, Valerie C., Kimmelman, Jonathan, Fergusson, Dean, Grimshaw, Jeremy M., Hackam, Dan G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3720257/
https://www.ncbi.nlm.nih.gov/pubmed/23935460
http://dx.doi.org/10.1371/journal.pmed.1001489

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